Balancing RNA processing and innate immune response: Possible roles for SMN condensates in snRNP biogenesis.

Maita, Hiroshi; Nakagawa, Shinichi

Balancing RNA processing and innate immune response: Possible roles for SMN condensates in snRNP biogenesis.

Maita, Hiroshi; Nakagawa, Shinichi

Biochimica et biophysica acta. General subjects, 2025, 1869(3), 130764

Permalink : https://hdl.handle.net/2115/97370

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/97370
タイトル	Balancing RNA processing and innate immune response: Possible roles for SMN condensates in snRNP biogenesis.
著者	e-Rad_Researcher 60431318 著者名 Maita, Hiroshi
著者	e-Rad_Researcher 50324679 著者名 Nakagawa, Shinichi
言語	英語
キーワード	U-body
	intrinsically disordered region
	SMN
	Tudor domain
	symmetrical arginine dimethylation
	Cajal body
	Coilin
発行日	2025-01-16
出版者	Elsevier
収録物名	Biochimica et biophysica acta. General subjects
巻(号)	1869(3)
ページ	130764
抄録	Biomolecular condensates like U-bodies are specialized cellular structures formed through multivalent interactions among intrinsically disordered regions. U-bodies sequester small nuclear ribonucleoprotein complexes (snRNPs) in the cytoplasm, and their formation in mammalian cells depends on stress conditions. Because of their location adjacent to P-bodies, U-bodies have been considered potential sites for snRNP storage or turnover. SMN, a chaperone for snRNP biogenesis, forms condensates through its Tudor domain. In fly models, defects in SMN trigger innate immune responses similar to those observed with excess cytoplasmic snRNA during viral infection in mammalian cells. Additionally, spinal muscular atrophy (SMA), caused by SMN deficiency, is associated with inflammation. Therefore, SMN may help prevent innate immune aberrant activation due to defective snRNP biogenesis by forming U-bodies to sequester these molecules. Further studies on U-body functions may provide therapeutic insights for diseases related to RNA metabolism.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1872-8006
関連情報	PMID 39826814
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbagen.2025.130764