open access

https://hdl.handle.net/2115/97382

Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer

英語

Subcutaneous adipose tissue

2025-01-08

John wiley & sons

Journal of hepato-biliary-pancreatic sciences

32(3)

194-202

Background High subcutaneous adipose tissue radiodensity (SATr), an indirect surrogate marker of adipose tissue quality, was associated with poor prognosis in various cancers. The present study aimed to assess the association of SATr with survival outcomes in patients with advanced biliary tract cancer (BTC). Methods This retrospective, single-center study included patients with unresectable or recurrent BTC who underwent chemotherapy/chemoradiotherapy. Overall survival (OS) and progression-free survival (PFS) were assessed using the log-rank test and the Cox proportional hazards model according to the SATr status. Results The study cohort included 234 patients, including 38 and 196 patients with high and non-high SATr, respectively. The median OS durations were 10.5 and 17.4 months (HR = 1.72, 95% CI: 1.19–2.49, p < .01) and the median PFS durations were 4.9 and 8.0 months (HR = 1.52, 95% CI: 1.05–2.20, p = .03) in patients with high and non-high SATr, respectively. By multivariate analysis, high SATr, neutrophil/lymphocyte ratio >5, modified Glasgow prognostic score 1–2, and serum carcinoembryonic antigen >5.0 ng/mL were predictors for OS (HR, 1.66, 2.42, 2.00, and 1.56, respectively; p < .05). By multivariate analysis, metastatic disease status, high SATr, neutrophil/lymphocyte ratio >5, and modified Glasgow prognostic score 1–2 were independent risk factors for worse PFS (HR, 1.56, 1.56, 1.81, and 1.57, respectively; p < .05). Conclusions High SATr was associated with risk of tumor progression and poor prognosis in patients with advanced BTC treated by palliative chemotherapy/chemoradiotherapy.

学術雑誌論文

Accepted Manuscript

This is the peer reviewed version of the following article: Sugiura R, Kawamoto Y, Kuwatani M, Kawakubo K, Harada K, Ohara M, et al. Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer. J Hepatobiliary Pancreat Sci. 2025; 32: 194–202., which has been published in final form at https://doi.org/10.1002/jhbp.12105. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.

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