Pre-operative left atrial size and functions are predictors of left atrial reverse remodelling after mitral valvuloplasty for myxomatous mitral valve disease in dogs

Kawamoto, S.; Nakamura, K.; Mori, T.; Wada, T.; Fujiwara, A.; Takiguchi, M.

Pre-operative left atrial size and functions are predictors of left atrial reverse remodelling after mitral valvuloplasty for myxomatous mitral valve disease in dogs

Kawamoto, S.; Nakamura, K.; Mori, T. et al.

Journal of veterinary cardiology, 2025, 57, 47-57

Permalink : https://hdl.handle.net/2115/97401

このアイテムのアクセス数:35件（2026-07-20 07:11 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/97401
タイトル	Pre-operative left atrial size and functions are predictors of left atrial reverse remodelling after mitral valvuloplasty for myxomatous mitral valve disease in dogs
著者	Kawamoto, S. ; Nakamura, K. ; Mori, T. ; Wada, T. ; Fujiwara, A. ; Takiguchi, M.
著者名 Kawamoto, S.
e-Rad_Researcher 80625898 著者名 Nakamura, K.
著者名 Mori, T.
著者名 Wada, T.
著者名 Fujiwara, A.
e-Rad_Researcher 70261336 著者名 Takiguchi, M.
言語	英語
キーワード	Mitral regurgitation
	Left atrial strain
	Speckle tracking echocardiography
	Booster pump function
	Reservoir function
発行日	2025-02
出版者	Elsevier
収録物名	Journal of veterinary cardiology
巻(号)	57
ページ	47-57
抄録	Objectives: The objective of this study was to determine alterations in left atrial size, function, and determinants of left atrial reverse remodelling (LARR) after mitral valvuloplasty (MVP) in dogs with myxomatous mitral valve disease. Animals: Thirty-seven dogs undergoing MVP were included in this study. Materials and Methods: Echocardiographic parameters, including left atrial (LA) strain, were evaluated at baseline, during the early postoperative period (within two weeks), and at one and three months postoperatively. Patients were divided into two groups based on the attainment of LARR, defined as a left atrial-to-aortic root ratio (LA:Ao) < 1.6 at three months. The predictors of LARR were analysed using univariate logistic regression analysis. Results: Left atrial-to-aortic root ratio significantly decreased in the early postoperative period (median: 1.68; lower and upper quartiles: 1.54-1.92) compared to that in baseline (2.41; 2.00-2.80), with a further significant reduction observed at three months (1.46; 1.34-1.63). Left atrial reverse remodelling was achieved in 27 (73%) patients. Baseline left atrial-to-aortic root ratio was higher, and peak atrial longitudinal strain and peak atrial contraction strain (PACS) were lower in the non-LARR group than in the LARR group. Among the baseline parameters, PACS was the strongest predictor of LARR (area under the curve: 0.837). Conclusions: Following MVP, the LA size decreased in the early postoperative period and continued to decrease over three months of follow-up. A low PACS score was the most reliable predictor of inadequate LARR. Further studies are necessary to determine the relationship between LARR, prognosis, and the optimal timing for surgical intervention.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1760-2734
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jvc.2024.10.007