Fully biosourced amphiphilic block copolymer from tamarind seed xyloglucan and solanesol: synthesis, aqueous self-assembly, and drug encapsulation

Lang, Weeranuch; Watanabe, Tomohisa; Lee, Chaehun; Tagami, Takayoshi; Li, Feng; Yamamoto, Takuya; Tajima, Kenji; Borsali, Redouane; Takahashi, Kenji; Satoh, Toshifumi; Isono, Takuya

Fully biosourced amphiphilic block copolymer from tamarind seed xyloglucan and solanesol: synthesis, aqueous self-assembly, and drug encapsulation

Lang, Weeranuch; Watanabe, Tomohisa; Lee, Chaehun et al.

Carbohydrate Polymers, 2025, 352, 123181

Permalink : https://hdl.handle.net/2115/97428

このアイテムのアクセス数:74件（2026-08-18 01:34 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/97428
タイトル	Fully biosourced amphiphilic block copolymer from tamarind seed xyloglucan and solanesol: synthesis, aqueous self-assembly, and drug encapsulation
著者	Lang, Weeranuch ; Watanabe, Tomohisa ; Lee, Chaehun ; Tagami, Takayoshi ; Li, Feng ; Yamamoto, Takuya ; Tajima, Kenji ; Borsali, Redouane ; Takahashi, Kenji ; Satoh, Toshifumi ; Isono, Takuya
著者名 Lang, Weeranuch
著者名 Watanabe, Tomohisa
著者名 Lee, Chaehun
e-Rad_Researcher 70709849 著者名 Tagami, Takayoshi
e-Rad_Researcher 30902788 著者名 Li, Feng
e-Rad_Researcher 30525986 著者名 Yamamoto, Takuya
e-Rad_Researcher 00271643 著者名 Tajima, Kenji
著者名 Borsali, Redouane
e-Rad_Researcher 00216714 著者名 Takahashi, Kenji
e-Rad_Researcher 80291235 著者名 Satoh, Toshifumi
e-Rad_Researcher 70740075 著者名 Isono, Takuya
言語	英語
キーワード	Biobased-block copolymers
	Drug solubilization
	Self-assembly
	Solanesol
	Tamarind seed xyloglucan
	Xyloglucan megalosaccharide
発行日	2025-03-15
出版者	Elsevier
収録物名	Carbohydrate Polymers
巻(号)	352
ページ	123181
抄録	This study aims to explore the development of natural bio-based amphiphilic block copolymers for drug delivery applications. We investigated block copolymers derived from tamarind seed xyloglucan and solanesol, focusing on their synthesis, structural analysis, aqueous self-assembly, and drug encapsulation. Specifically, xyloglucan hydrolysate segments with number-average degrees of polymerization (DPs) of between 8 and 44 (XOS8, XMS10, XMS16, XMS28, and XMS44) were used as the hydrophilic blocks, whereas plant-sourced solanesol was selected as the hydrophobic segment. These two segments were linked via click chemistry to create novel XOS-b-Sol and XMS-b-Sol copolymers, where XOS refers to a xyloglucan oligosaccharide (DP < 10), and XMS denotes a megalosaccharide, defined as a larger xyloglucan polymer with a DP >10. XMS10- and XMS16-b-Sol self-assembled in aqueous media to form predominantly narrowly dispersed spherical micelles, while XOS8-b-Sol exhibited a combination of short wormlike structures and spherical micelles. Small-angle X-ray scattering, multi-angle dynamic light scattering, and transmission electron microscopy revealed the XMS28- and XMS44-b-Sol micelles are morphologically diverse. XMS10-b-Sol solubilized quercetin, a water-insoluble flavonoid, highly effectively, highlighting its potential as an environmentally benign drug carrier.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© <2025>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0144-8617
関連情報	PMID 39843085
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.carbpol.2024.123181