Identification of flexixanthin and its derivatives in Algoriphagus bacteria and evaluation of their antioxidant and anti-inflammatory effects

Takatani, Naoki; Sato-Takabe, Yuki; Aoike, Misaki; Sekine, Rika; Maoka, Takashi; Sawabe, Tomoo; Beppu, Fumiaki; Shindo, Kazutoshi; Hosokawa, Masashi

Identification of flexixanthin and its derivatives in Algoriphagus bacteria and evaluation of their antioxidant and anti-inflammatory effects

Takatani, Naoki; Sato-Takabe, Yuki; Aoike, Misaki et al.

Food Bioscience, 2025, 65

Permalink : https://hdl.handle.net/2115/97448

このアイテムのアクセス数:24件（2026-07-14 18:40 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/97448
タイトル	Identification of flexixanthin and its derivatives in Algoriphagus bacteria and evaluation of their antioxidant and anti-inflammatory effects
著者	Takatani, Naoki ; Sato-Takabe, Yuki ; Aoike, Misaki ; Sekine, Rika ; Maoka, Takashi ; Sawabe, Tomoo ; Beppu, Fumiaki ; Shindo, Kazutoshi ; Hosokawa, Masashi
e-Rad_Researcher 40801501 著者名 Takatani, Naoki
著者名 Sato-Takabe, Yuki
著者名 Aoike, Misaki
著者名 Sekine, Rika
e-Rad_Researcher 10157159 著者名 Maoka, Takashi
e-Rad_Researcher 30241376 著者名 Sawabe, Tomoo
e-Rad_Researcher 10707540 著者名 Beppu, Fumiaki
著者名 Shindo, Kazutoshi
e-Rad_Researcher 10241374 著者名 Hosokawa, Masashi
言語	英語
キーワード	Monocyclic carotenoids
	Algoriphagus
	Flexixanthin
	2 '-Hydroxyflexixanthin
	2-Hydroxyflexixanthin
	Antioxidant activity
	Anti-inflammatory activity
発行日	2025-03
出版者	Elsevier
収録物名	Food Bioscience
巻(号)	65
抄録	The genus Algoriphagus comprises a group of red-colored, Gram-negative, aerobic bacteria that inhabit various marine environments. Several species of Algoriphagus produce the keto-monocyclic carotenoid flexixanthin; however, information on its derivatives and their biological activities is limited. In this study, Algoriphagus sp. strain Fs4 was isolated from the surface of seaweed collected at Nanaehama, Hokkaido, Japan. Based on structural analysis via nuclear magnetic resonance spectroscopy, of the carotenoid produced by the strain, it was identified as 2 '-hydroxyflexixanthin, a new carotenoid in the genus Algoriphagus. A comparison of the carotenoid profiles of 25 species of Algoriphagus bacteria revealed that flexixanthin was present in all strains, and some strains also produced 2- or 2 '-hydroxyflexixanthin. The biological activities of flexixanthin and its derivatives were evaluated in terms of their antioxidant and anti-inflammatory effects against macrophages. The degree of inhibitory effect on lipid peroxidation was in the order: 2-hydroxyflexixanthin > 2 '-hydroxyflexixanthin > flexixanthin. Conversely, flexixanthin significantly inhibited lipopolysaccharide-induced interleukin-1(3 and -6, and nitric oxide synthase 2 mRNA expression, demonstrating a stronger inhibitory effect than that of 2 ' hydroxyflexixanthin; 2-hydroxyflexixanthin showed no significant inhibitory effects. These results indicate that the introduction of hydroxyl groups at specific sites affects the antioxidant and anti-inflammatory activities of flexixanthin. The findings of this study highlights the potential of the genus Algoriphagus as a source of flexixanthin and its derivatives and provides a basis for the future application of these monocyclic carotenoids in the production of nutraceuticals and pharmaceuticals.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	2212-4306
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.fbio.2025.106015