Long-term outcome and social-intellectual ability of patients with basal ganglia germinoma

Okamoto, Michinari; Yamaguchi, Shigeru; Sawaya, Ryosuke; Ishi, Yukitomo; Motegi, Hiroaki; Terashita, Yukayo; Sugiyama, Minako; Cho, Yuko; Nishioka, Kentaro; Mori, Takashi; Hashimoto, Takayuki; Aoyama, Hidefumi; Manabe, Atsushi; Fujimura, Miki

Long-term outcome and social-intellectual ability of patients with basal ganglia germinoma

Okamoto, Michinari; Yamaguchi, Shigeru; Sawaya, Ryosuke et al.

Pediatric Neurology, 2025, 165, 16-21

Permalink : https://hdl.handle.net/2115/97480

このアイテムのアクセス数:64件（2026-10-16 18:03 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/97480
タイトル	Long-term outcome and social-intellectual ability of patients with basal ganglia germinoma
著者	Okamoto, Michinari ; Yamaguchi, Shigeru ; Sawaya, Ryosuke ; Ishi, Yukitomo ; Motegi, Hiroaki ; Terashita, Yukayo ; Sugiyama, Minako ; Cho, Yuko ; Nishioka, Kentaro ; Mori, Takashi ; Hashimoto, Takayuki ; Aoyama, Hidefumi ; Manabe, Atsushi ; Fujimura, Miki
著者名 Okamoto, Michinari
e-Rad_Researcher 70399939 著者名 Yamaguchi, Shigeru
著者名 Sawaya, Ryosuke
e-Rad_Researcher 30812284 著者名 Ishi, Yukitomo
e-Rad_Researcher 40748844 著者名 Motegi, Hiroaki
著者名 Terashita, Yukayo
著者名 Sugiyama, Minako
著者名 Cho, Yuko
e-Rad_Researcher 80463743 著者名 Nishioka, Kentaro
著者名 Mori, Takashi
e-Rad_Researcher 60400678 著者名 Hashimoto, Takayuki
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
e-Rad_Researcher 20292849 著者名 Manabe, Atsushi
e-Rad_Researcher 00361098 著者名 Fujimura, Miki
言語	英語
キーワード	Basal ganglia
	Intelligence quotient
	Intracranial germ cell tumors
	Germinoma
	Social activity
	Whole brain irradiation
発行日	2025-01-16
出版者	Elsevier
収録物名	Pediatric Neurology
巻(号)	165
ページ	16-21
抄録	Background: In this study, we aimed at delineating the still ambiguous clinical characteristics and longterm outcomes of basal ganglia (BG) germinoma from the aspect of recurrence-free survival as well as social and intellectual activity. Methods: We retrospectively reviewed medical records and imaging data for 12 patients with BG germinoma diagnosed and treated between 1996 and 2020, collecting the most recent status via medical records or telephone from the patients. Results: The tumors involved the right and left sides and bilateral locations in three, seven, and two cases, respectively. The median follow-up period was 179 months. Six patients exhibited onset neuropsychologic symptoms, for example, cognitive decline or behavior disorder. We evaluated the intelligence quotient (IQ) in 10 patients and observed significantly lower IQ scores in six patients with neuropsychologic symptoms. Patients with right-sided lesions displayed average IQ levels (median 106), whereas those with left-sided or bilateral lesions had reduced IQ (median 67). A complete response was achieved by primary chemoradiotherapy in all patients. Three patients who underwent focal or wholeventricle irradiation experienced recurrence, whereas no recurrence was observed in patients who received whole-brain irradiation (WBI). Concerning the neurocognitive outcomes, three and six patients with unilateral right and left lesions were living self-independently (Karnofsky Performance Status [KPS] S 70), whereas the three remaining patients (one with left and two with bilateral lesions) had a dependent status (KPS <70). Conclusions: WBI is crucial for disease control in BG germinoma. Furthermore, lesion laterality might affect neuropsychologic symptoms including IQ at diagnosis and neurocognitive outcomes in BG germinoma.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0887-8994
EISSN	1873-5150
関連情報	PMID 39922138
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.pediatrneurol.2025.01.009