Phosphate Flame Retardants and Plasticizers and Their Association with Reproductive and Steroid Hormone Levels among Peripubertal-Aged Children : The Hokkaido Birth Cohort Study

Ikeda, Atsuko; Yamaguchi, Takeshi; Bamai, Yu Ait; Roggeman, Maarten; Ikenaka, Yoshinori; Zeng, Yi; Yasuda, Ayaka; Ketema, Rahel Mesfin; Marsela, Megasari; Gys, Celine; den Ouden, Fatima; Itoh, Sachiko; Nakamura, Akie; Kitta, Takeya; Kon, Masafumi; Manabe, Atsushi; Covaci, Adrian; Kishi, Reiko

Phosphate Flame Retardants and Plasticizers and Their Association with Reproductive and Steroid Hormone Levels among Peripubertal-Aged Children : The Hokkaido Birth Cohort Study

Ikeda, Atsuko; Yamaguchi, Takeshi; Bamai, Yu Ait et al.

Environmental science & technology, 2025, 59(10), 4820-4831

Permalink : https://hdl.handle.net/2115/97556

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アクセス権	open access
URI	https://hdl.handle.net/2115/97556
タイトル	Phosphate Flame Retardants and Plasticizers and Their Association with Reproductive and Steroid Hormone Levels among Peripubertal-Aged Children : The Hokkaido Birth Cohort Study
著者	Ikeda, Atsuko ; Yamaguchi, Takeshi ; Bamai, Yu Ait ; Roggeman, Maarten ; Ikenaka, Yoshinori ; Zeng, Yi ; Yasuda, Ayaka ; Ketema, Rahel Mesfin ; Marsela, Megasari ; Gys, Celine ; den Ouden, Fatima ; Itoh, Sachiko ; Nakamura, Akie ; Kitta, Takeya ; Kon, Masafumi ; Manabe, Atsushi ; Covaci, Adrian ; Kishi, Reiko
ORCID 0000-0002-3065-262X 著者名 Ikeda, Atsuko
e-Rad_Researcher 80894972 著者名 Yamaguchi, Takeshi
e-Rad_Researcher 90752907 著者名 Bamai, Yu Ait
ORCID 0000-0002-6643-4907 著者名 Roggeman, Maarten
e-Rad_Researcher 40543509 著者名 Ikenaka, Yoshinori
e-Rad_Researcher 00999617 著者名 Zeng, Yi
ORCID 0009-0009-8552-0622 著者名 Yasuda, Ayaka
e-Rad_Researcher 60964822 著者名 Ketema, Rahel Mesfin
e-Rad_Researcher 60978914 著者名 Marsela, Megasari
著者名 Gys, Celine
ORCID 0000-0001-6862-6059 著者名 den Ouden, Fatima
e-Rad_Researcher 90580936 著者名 Itoh, Sachiko
e-Rad_Researcher 90724708 著者名 Nakamura, Akie
e-Rad_Researcher 40374441 著者名 Kitta, Takeya
e-Rad_Researcher 40802799 著者名 Kon, Masafumi
e-Rad_Researcher 20292849 著者名 Manabe, Atsushi
ORCID 0000-0003-0527-1136 著者名 Covaci, Adrian
e-Rad_Researcher 80112449 著者名 Kishi, Reiko
言語	英語
キーワード	children
	organophosphate triesters
	phosphateflame retardants
	endocrine disrupting chemicals
	puberty
	menarche
	cross-sectional
発行日	2025-03-09
出版者	American Chemical Society
収録物名	Environmental science & technology
巻(号)	59(10)
ページ	4820-4831
ページ数	12
抄録	This cross-sectional study investigated associations between exposure to organophosphate flame retardants and plasticizers (PFRs) and reproductive and steroid hormones in peripubertal children from the Hokkaido Birth Cohort (429 children aged 9-12 years; between September 2017 and March 2020). Thirteen urinary PFR metabolites and 14 plasma steroid hormones were investigated using LC-MS/MS and four reproductive hormones were investigated using immunoassays. Linear regression for single PFR, quantile g-computation, and Bayesian machine kernel regression (BKMR) models for the PFR mixtures were used to examine the association between hormones and PFRs. Among boys, significant positive associations were observed between estradiol and ΣTCIPP and ΣTBOEP, and inverse associations were identified between insulin-like factor-3 (INSL3) and ΣTCIPP, and between luteinizing hormone (LH) and ΣEHDPHP. The PFR mixture was associated with the trends of increasing estradiol and androstenedione, and decreasing cortisol, cortisone, LH, inhibin B, and INSL3. Among girls, androstenedione and ΣTCIPP, testosterone and ΣEHDPHP, (androstenedione + testosterone)/DHEA-S and ΣTCIPP, and ΣEHDPHP and ΣTPHP were significantly correlated. The PFR mixture showed trends of increasing testosterone, androstenedione, and inhibin B, and decreasing cortisol, cortisone, and INSL3. Individual PFRs and PFR mixtures altered steroids and reproductive hormones in peripubertal children.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN	0013-936X
NCID	AA00637524
関連情報	PMID 40057849
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1021/acs.est.4c11436