Alendronate inhibits bone-specific blood vessels in the femoral metaphyses of mice

Hasegawa, Tomoka; Sakakibara, Mako; Liu, Xuanyu; Yoshino, Hirona; Shi, Yan; Cui, Jiaxin; Haraguchi-Kitakamae, Mai; Li, Weisong; Haoyu, Wang; Yamamoto, Tomomaya; Ishizu, Hotaka; Sekiguchi, Tamaki; Shimizu, Tomohiro; Amizuka, Norio

Alendronate inhibits bone-specific blood vessels in the femoral metaphyses of mice

Hasegawa, Tomoka; Sakakibara, Mako; Liu, Xuanyu et al.

Journal of oral biosciences, 2025, 67(2), 100655

Permalink : https://hdl.handle.net/2115/97811

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アクセス権	open access
URI	https://hdl.handle.net/2115/97811
タイトル	Alendronate inhibits bone-specific blood vessels in the femoral metaphyses of mice
著者	Hasegawa, Tomoka ; Sakakibara, Mako ; Liu, Xuanyu ; Yoshino, Hirona ; Shi, Yan ; Cui, Jiaxin ; Haraguchi-Kitakamae, Mai ; Li, Weisong ; Haoyu, Wang ; Yamamoto, Tomomaya ; Ishizu, Hotaka ; Sekiguchi, Tamaki ; Shimizu, Tomohiro ; Amizuka, Norio
e-Rad_Researcher 50739349 著者名 Hasegawa, Tomoka
著者名 Sakakibara, Mako
著者名 Liu, Xuanyu
著者名 Yoshino, Hirona
著者名 Shi, Yan
著者名 Cui, Jiaxin
著者名 Haraguchi-Kitakamae, Mai
著者名 Li, Weisong
著者名 Haoyu, Wang
e-Rad_Researcher 50928299 著者名 Yamamoto, Tomomaya
著者名 Ishizu, Hotaka
e-Rad_Researcher 80580943 著者名 Sekiguchi, Tamaki
e-Rad_Researcher 60784246 著者名 Shimizu, Tomohiro
e-Rad_Researcher 30242431 著者名 Amizuka, Norio
言語	英語
キーワード	Vascular endothelial cells
	Alendronate
	Osteoblast
	Osteoclast
	Endomucin
発行日	2025-03-19
出版者	Elsevier
収録物名	Journal of oral biosciences
巻(号)	67(2)
ページ	100655
抄録	To determine whether alendronate affects vascular endothelial cells and regulates the interactions between blood vessels and osteoblasts, we have examined the femoral metaphyses of alendronate-administered mice. Following administration, the bone-specific blood vessels exhibited significantly reduced luminal diameters and rough luminal surfaces with numerous small protrusions and vesicles. Although the osteoclast distribution remained unchanged in alendronate-treated mice, osteoblasts were inactivated in the metaphyseal regions where blood vessels had shrunk. Additionally, the expression of genes such as Ephb4/Efnb2, which mediate vascular endothelial cell-osteoblast interactions, was diminished. Therefore, alendronate may primarily affect bone-specific blood vessels, thus leading to osteoblast inactivation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1349-0079
EISSN	1880-3865
関連情報	PMID 40118179
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.job.2025.100655