Laparoscopic distal pancreatectomy for multiple pancreatic solid pseudopapillary neoplasms with marked calcification in a middle-aged female

Sakamoto, Yuzuru; Aimono, Eriko; Takishin, Yunosuke; Muranaka, Tetsuhito; Kurose, Tomoya; Ishikawa, Takaya; Shoji, Hirotaka; Nakamoto, Hiroki; Oshima, Takahiro; Taketomi, Akinobu

Laparoscopic distal pancreatectomy for multiple pancreatic solid pseudopapillary neoplasms with marked calcification in a middle-aged female

Sakamoto, Yuzuru; Aimono, Eriko; Takishin, Yunosuke et al.

Clinical journal of gastroenterology, 2025, 18(4), 727-733

Permalink : https://hdl.handle.net/2115/97863

このアイテムのアクセス数:43件（2026-08-12 03:51 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/97863
タイトル	Laparoscopic distal pancreatectomy for multiple pancreatic solid pseudopapillary neoplasms with marked calcification in a middle-aged female
著者	Sakamoto, Yuzuru ; Aimono, Eriko ; Takishin, Yunosuke ; Muranaka, Tetsuhito ; Kurose, Tomoya ; Ishikawa, Takaya ; Shoji, Hirotaka ; Nakamoto, Hiroki ; Oshima, Takahiro ; Taketomi, Akinobu
e-Rad_Researcher 20876247 著者名 Sakamoto, Yuzuru
著者名 Aimono, Eriko
著者名 Takishin, Yunosuke
著者名 Muranaka, Tetsuhito
著者名 Kurose, Tomoya
著者名 Ishikawa, Takaya
著者名 Shoji, Hirotaka
著者名 Nakamoto, Hiroki
著者名 Oshima, Takahiro
e-Rad_Researcher 70363364 著者名 Taketomi, Akinobu
言語	英語
キーワード	Solid pseudopapillary neoplasms
	Multiple
	Pancreas
	Old female
	Laparoscopic distal pancreatectomy
発行日	2025-05-26
出版者	Springer
収録物名	Clinical journal of gastroenterology
巻(号)	18(4)
ページ	727-733
抄録	Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low-grade malignant tumor that primarily affects young females. Multiple SPNs, particularly in older females, are extremely rare. While these tumors generally have a good prognosis, some may progress to malignancy. A 66-year-old female presented with back pain, and CT revealed two calcified masses in the pancreas. The tumor marker levels were normal, and contrast-enhanced CT, ultrasound, and MRI findings suggested multiple SPNs. Owing to significant calcification, preoperative biopsy was not feasible, so laparoscopic distal pancreatectomy (LDP) was performed for diagnosis and treatment. Histopathological examination revealed tumor cells with a round morphology, which were arranged in nested formations, along with areas of calcification on H&E staining. Immunohistochemical analysis revealed positive staining for CD56, vimentin, and beta-catenin, whereas bcl-10 was negative, supporting the definitive diagnosis of multiple SPNs. Although SPNs generally have a good prognosis, recurrence is possible, emphasizing the need for complete resection and long-term follow-ups. Even when preoperative biopsy is difficult due to calcification, aggressive surgical resection is crucial for long-term successful prognoses. Furthermore, LDP offers advantages over traditional open surgery, such as reduced blood loss and faster recovery, and may be considered for diagnosis and treatment in such cases.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12328-025-02152-9
PISSN	1865-7257
関連情報	PMID 40418297
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12328-025-02152-9