Clinical characteristics of multiple evanescent white dot syndrome with poor visual prognosis in Japanese patients

Tanaka, Takayuki; Saito, Michiyuki; Kase, Satoru; Dong, Zhenyu; Ando, Ryo; Namba, Kenichi; Nishiyama-Hirooka, Kiriko; Yamashita, Yui; Ishida, Susumu

Clinical characteristics of multiple evanescent white dot syndrome with poor visual prognosis in Japanese patients

Tanaka, Takayuki; Saito, Michiyuki; Kase, Satoru et al.

Graefe's Archive For Clinical and Experimental Ophthalmology, 2025, 263(9), 2551-2559

Permalink : https://hdl.handle.net/2115/97968

このアイテムのアクセス数:30件（2026-07-14 18:38 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/97968
タイトル	Clinical characteristics of multiple evanescent white dot syndrome with poor visual prognosis in Japanese patients
著者	Tanaka, Takayuki ; Saito, Michiyuki ; Kase, Satoru ; Dong, Zhenyu ; Ando, Ryo ; Namba, Kenichi ; Nishiyama-Hirooka, Kiriko ; Yamashita, Yui ; Ishida, Susumu
e-Rad_Researcher 40793633 著者名 Tanaka, Takayuki
e-Rad_Researcher 90443944 著者名 Saito, Michiyuki
著者名 Kase, Satoru
e-Rad_Researcher 00443945 著者名 Dong, Zhenyu
e-Rad_Researcher 60399847 著者名 Ando, Ryo
e-Rad_Researcher 70333599 著者名 Namba, Kenichi
著者名 Nishiyama-Hirooka, Kiriko
著者名 Yamashita, Yui
e-Rad_Researcher 10245558 著者名 Ishida, Susumu
言語	英語
キーワード	Multiple evanescent white dot syndrome (MEWDS)
	Primary MEWDS
	Secondary MEWDS
発行日	2025-07-04
出版者	Springer
収録物名	Graefe's Archive For Clinical and Experimental Ophthalmology
巻(号)	263(9)
ページ	2551-2559
抄録	Purpose Multiple evanescent white dot syndrome (MEWDS) typically resolves spontaneously and is expected to have a favorable visual prognosis. Therefore, the initial manifestations of MEWDS have yet to be well studied. This study aimed to investigate the clinical characteristics of primary and secondary MEWDS patients and evaluate factors responsible for poor visual prognosis. Methods The medical records of 36 patients diagnosed with MEWDS between 2004 and 2021 at Hokkaido University Hospital were retrospectively reviewed. The study evaluated patient demographics, clinical characteristics, and multimodal imaging findings. The clinical factors involving final logMAR best-corrected visual acuity (BCVA) were analyzed. In addition, clinical characteristics of secondary MEWDS cases with poor visual prognosis were investigated. Results Twelve of the 36 patients (33.3%) had active chorioretinal lesions distinct from MEWDS lesions, resulting in a prevalence of secondary MEWDS of 33.3%. Four patients presented with foveal active chorioretinal lesions (11.1%). Retinal atrophy developed in these lesions in all four cases during the follow-up period. Compared to primary MEWDS, secondary MEWDS with foveal involvement of active chorioretinal lesions was associated with significantly worse visual acuity at the initial visit (p = 0.004), and showed a trend toward poorer visual acuity was also observed at the final visit (p = 0.11). In simple linear regression analysis, coexisting foveal involvement of active chorioretinal lesions was significantly associated with worse final logMAR BCVA (p = 0.002). In multiple stepwise linear regression analysis, coexisting foveal involvement (p < 0.001) and male sex (p = 0.03) remained independently associated with poorer visual outcomes. Conclusions The presence of foveal active chorioretinal lesions in MEWDS may be associated with poorer visual prognosis.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00417-025-06872-z
PISSN	0721-832X
EISSN	1435-702X
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00417-025-06872-z