Structural Insights into Autophagy in the AlphaFold Era

Maruyama, Tatsuro; Noda, Nobuo N.

Journal of Molecular Biology, 2025, 437(18), 169235

Permalink : https://hdl.handle.net/2115/98004

このアイテムのアクセス数:22件（2026-10-17 11:55 集計）

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/98004
タイトル
Structural Insights into Autophagy in the AlphaFold Era
著者
著者名
Maruyama, Tatsuro
e-Rad_Researcher
40396297
著者名
Noda, Nobuo N.
言語
英語
キーワード
AlphaFold
AlphaFold2
AlphaFold3
Autophagosome formation
Autophagy
発行日
2025-09-15
出版者
Elsevier
収録物名
Journal of Molecular Biology
巻(号)
437(18)
ページ
169235
抄録
Autophagy, a lysosomal intracellular degradation system, is characterized by the de novo biogenesis of autophagosomes. This biogenesis is mediated by approximately 20 core Atg proteins, exhibiting a high degree of conservation from yeast to humans. Over the preceding two decades, the structural biology of autophagy has been investigated predominantly through X-ray crystallography, NMR spectroscopy, and, more recently, cryo-electron microscopy, collectively contributing to the elucidation of the structural basis of core Atg proteins. The recent introduction of AlphaFold has significantly improved the precision of structure prediction and is transforming structural biology research. In this review, we aim to synthesize the structural basis of the operational mechanisms of the core Atg proteins, employing structures predicted by AlphaFold, and to discuss the molecular mechanisms that drive autophagosome biogenesis.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報
© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN
0022-2836
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.jmb.2025.169235