Physicochemical properties and apatite precipitation behavior of experimental calcium silicate-based cements doped with phosphate compounds

Tsuchiya, Kenta; Sauro, Salvatore; Sano, Hidehiko; Matinlinna, Jukka P.; Yamauti, Monica; Hoshika, Shuhei; Toida, Yu; Islam, Rafiqul; Tomokiyo, Atsushi

Physicochemical properties and apatite precipitation behavior of experimental calcium silicate-based cements doped with phosphate compounds

Tsuchiya, Kenta; Sauro, Salvatore; Sano, Hidehiko et al.

Dental materials, 2025, 41(9), 1058-1066

Permalink : https://hdl.handle.net/2115/98006

このアイテムのアクセス数:26件（2026-08-12 18:22 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/98006
タイトル	Physicochemical properties and apatite precipitation behavior of experimental calcium silicate-based cements doped with phosphate compounds
著者	Tsuchiya, Kenta ; Sauro, Salvatore ; Sano, Hidehiko ; Matinlinna, Jukka P. ; Yamauti, Monica ; Hoshika, Shuhei ; Toida, Yu ; Islam, Rafiqul ; Tomokiyo, Atsushi
e-Rad_Researcher 71018629 著者名 Tsuchiya, Kenta
著者名 Sauro, Salvatore
e-Rad_Researcher 90205998 著者名 Sano, Hidehiko
著者名 Matinlinna, Jukka P.
e-Rad_Researcher 10833965 著者名 Yamauti, Monica
e-Rad_Researcher 40581682 著者名 Hoshika, Shuhei
e-Rad_Researcher 20844450 著者名 Toida, Yu
e-Rad_Researcher 00906414 著者名 Islam, Rafiqul
e-Rad_Researcher 20507777 著者名 Tomokiyo, Atsushi
言語	英語
キーワード	Mineral trioxide aggregate
	Calcium silicate cement
	Hydroxyapatite
	Bioactivity
	Endodontics
発行日	2025-09
出版者	Elsevier
収録物名	Dental materials
巻(号)	41(9)
ページ	1058-1066
抄録	Objectives: This study aims to evaluate the solubility, pH, Ca2 + release, setting time, and hydroxyapatite (HAp) formation of the tested materials. Methods: Four study groups were tested: NEX-MTA (NMTA; GC, Japan), NMTA with phosphorylated pullulan (MTA-PPL), NMTA with poly-PS (MTA-polyPS), and Biodentine (BD; Septodont, France). Solubility was measured after 7 and 28 days at 37 degrees C in deionized water. Ca2+ release and pH evaluation were performed after immersion in deionized water at 3 h, 24 h, 7 days, and 28 days using pH and Ca2+ meters. Setting times were determined with a Vicat apparatus, and apatite precipitation was evaluated through scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/ EDS) and Fourier transform infrared spectroscopy (FTIR) analysis 28 days in phosphate-buffered saline. Results: <span style="background-color:inherit">NMTA showed the lowest solubility; however, there was no statistically significant difference between NMTA and MTA-polyPS (P > 0.05)</span><strong style="background-color:inherit">.<span style="background-color:inherit"> NMTA exhibited the most alkaline pH at all measured time points. Although MTA-polyPS consistently showed lower pH values than NMTA throughout the observation periods, no statistically significant differences were observed among MTA-polyPS, BD, and MTA-PPL at 28 days (P > 0.05). BD released the most Ca</span>2+</SUP><span style="background-color:inherit">, with MTA-polyPS releasing the least. BD exhibited the shortest initial and final setting time (9.2 and 42 min, respectively), followed by MTA-polyPS, MTA-PPL, and NMTA. SEM/ EDS and FTIR indicated that MTA-polyPS had the highest apatite precipitation, with Ca/P ratios of 1.70 (NMTA) and 1.79 (MTA-polyPS). MTA-PPL and BD showed no significant apatite precipitation, with Ca/P ratios of 3.93 and 34.9, respectively.</span> Significance: The incorporation of polyPS into calcium silicate-based cement may enhance apatite precipitation and accelerate the setting without altering the pH and solubility property.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2005. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0109-5641
関連情報	PMID 40544036
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.dental.2025.06.014