Physical activity, sedentary time and sperm DNA fragmentation index in healthy Japanese men

Li, Hongxuan; Hao, Wen; Maeda, Eri; Kumazawa, Yukiyo; Takahashi, Kazumasa; Tanaka, Takashi; Yokota, Isao; Terada, Yukihiro; Nomura, Kyoko; Okada, Hiroshi; Tamakoshi, Akiko

Physical activity, sedentary time and sperm DNA fragmentation index in healthy Japanese men

Li, Hongxuan; Hao, Wen; Maeda, Eri et al.

Reproductive Biomedicine Online, 2025, 51(4), 105015

Permalink : https://hdl.handle.net/2115/98014

このアイテムのアクセス数:69件（2026-08-16 22:42 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/98014
タイトル	Physical activity, sedentary time and sperm DNA fragmentation index in healthy Japanese men
著者	Li, Hongxuan ; Hao, Wen ; Maeda, Eri ; Kumazawa, Yukiyo ; Takahashi, Kazumasa ; Tanaka, Takashi ; Yokota, Isao ; Terada, Yukihiro ; Nomura, Kyoko ; Okada, Hiroshi ; Tamakoshi, Akiko
著者名 Li, Hongxuan
著者名 Hao, Wen
e-Rad_Researcher 30778395 著者名 Maeda, Eri
著者名 Kumazawa, Yukiyo
著者名 Takahashi, Kazumasa
著者名 Tanaka, Takashi
e-Rad_Researcher 20761414 著者名 Yokota, Isao
著者名 Terada, Yukihiro
著者名 Nomura, Kyoko
著者名 Okada, Hiroshi
e-Rad_Researcher 90236737 著者名 Tamakoshi, Akiko
言語	英語
キーワード	Fertility
	Semen quality
	Physical activity
	Sedentary time
	DNA fragmentation index
発行日	2025-04-17
出版者	Elsevier
収録物名	Reproductive Biomedicine Online
巻(号)	51(4)
ページ	105015
抄録	Research question: Are physical activity and sedentary time associated with the DNA fragmentation index (DFI) score and conventional semen parameters in healthy Japanese men? Design: Baseline data from the Preconception Research and Education Study for Men, an ongoing randomized controlled trial, were used to assess the long-term effects of preconception health education on male fertility. This cross-sectional analysis included 323 men, aged 20-39 years, recruited from September 2021 to December 2022 at workplace health check-up sites in Japan. Demographic, lifestyle and health check-up data were collected, and physical activity and sedentary time were measured using the International Physical Activity Questionnaire-Short Form. Semen quality was assessed using the DFI score and conventional semen analyses. Generalized linear models were used to evaluate the associations between physical activity, sedentary time and semen parameters, adjusting for confounders. Results: Higher total physical activity was associated with a lower DFI score (P-value for trend = 0.002), with the third and fourth total physical activity quartiles showing a 21% (95% CI 5-34%, P = 0.013) and a 29% (95% CI 12-43%, P = 0.002) reduction in DFI score compared with the first quartile reference, respectively. There was a trend for a shorter sedentary time to be associated with a lower DFI score, but this failed to reach significance (P-value for trend = 0.057). The first sedentary time quartile showed a 22% reduction in DFI score compared with the fourth quartile reference (95% CI 3-37%, P = 0.024). There were no significant associations between total physical activity, sedentary time and conventional semen parameters. Conclusions: Higher physical activity and shorter sedentary time are associated with a lower DFI score in Japanese men. However, these associations were not observed with conventional semen parameters.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1472-6483
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.rbmo.2025.105015