Emergence of livestock-associated MRSA clonal complex 398 in Thailand's swine industry

Narongpun, Pawarut; Chanchaithong, Pattrarat; Tanomsridachchai, Wimonrat; Nuanmuang, Narong; Thapa, Jeewan; Yamagishi, Junya; Suthienkul, Orasa; Leekitcharoenphon, Pimlapas; Aarestrup, Frank M.; Nakajima, Chie; Suzuki, Yasuhiko

Emergence of livestock-associated MRSA clonal complex 398 in Thailand's swine industry

Narongpun, Pawarut; Chanchaithong, Pattrarat; Tanomsridachchai, Wimonrat et al.

Journal of Antimicrobial Chemotherapy, 2025

Permalink : https://hdl.handle.net/2115/98032

このアイテムのアクセス数:5件（2026-09-06 08:35 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
NARONGPUN et al_2025.06.24	pdf	371 KB	8

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/98032
タイトル	Emergence of livestock-associated MRSA clonal complex 398 in Thailand's swine industry
著者	Narongpun, Pawarut ; Chanchaithong, Pattrarat ; Tanomsridachchai, Wimonrat ; Nuanmuang, Narong ; Thapa, Jeewan ; Yamagishi, Junya ; Suthienkul, Orasa ; Leekitcharoenphon, Pimlapas ; Aarestrup, Frank M. ; Nakajima, Chie ; Suzuki, Yasuhiko
著者名 Narongpun, Pawarut
著者名 Chanchaithong, Pattrarat
著者名 Tanomsridachchai, Wimonrat
著者名 Nuanmuang, Narong
著者名 Thapa, Jeewan
著者名 Yamagishi, Junya
著者名 Suthienkul, Orasa
著者名 Leekitcharoenphon, Pimlapas
著者名 Aarestrup, Frank M.
著者名 Nakajima, Chie
著者名 Suzuki, Yasuhiko
言語	英語
発行日	2025
出版者	Oxford University Press
収録物名	Journal of Antimicrobial Chemotherapy
抄録	Background Livestock-associated MRSA (LA-MRSA) clonal complex (CC) 398 is primarily found among pigs across Europe. However, CC398 has also been sporadically identified in several Asian countries, including Thailand. This study aimed to examine the drivers contributing to the emergence of LA-MRSA CC398 in Thailand's swine industry.Methods Whole-genome sequencing data of 18 LA-MRSA CC398 isolates from pigs, retail pork and swine workers in Thailand were analysed. Additionally, a total of 1197 qualified genomes from various sources in 24 countries were retrieved from Pathogenwatch. Subsequently, two SNP-based phylogenetic trees were reconstructed using maximum likelihood (n = 1215) and Bayesian inference (n = 168).Results Our findings revealed that Staphylococcus aureus isolates with the CC398-SCCmec Vc (5C2&5)-t034 genotype were closely related to European isolates, including those from Denmark. In contrast, S. aureus isolates belonging to the CC398-composite SCCmec-t034 formed a phylogenetically distinct cluster.Conclusions This study reports that the CC398-SCCmec Vc (5C2&5)-t034 genotype identified in Thai pigs may have originated from Danish swine populations, possibly introduced into Thailand through international livestock movement. The CC398-composite SCCmec-t034 genotype was also detected in domestic pigs; however, it appears to have evolved independently from the CC398-SCCmec Vc (5C2&5)-t034 genotype. Bayesian phylogenetic analysis estimates that the common ancestor of the composite genotype emerged earlier than that of the CC398-SCCmec Vc (5C2&5)-t034 genotype, indicating a separate evolutionary origin.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0305-7453
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/jac/dkaf313