open access

https://hdl.handle.net/2115/98040

Sema3A-and ascorbate-functionalized apatite-collagen scaffolds for enhanced bone regeneration

英語

Biomaterial

2025-08-21

Springer

MRS Communications

15

1105-1112

Porous collagen sponges coated with low-crystalline apatite are promising bone tissue regeneration scaffolds owing to their chemical similarity to natural bones. We previously fabricated an apatite-coated collagen sponge loaded with an osteogenic agent L-ascorbic acid 2-phosphate (AS), using a biomimetic coating process, demonstrating its superior functionality. In the present study, this sponge was further functionalized with another osteogenic agent, semaphorin 3A (S3). The collagen sponge was first coated with AS-immobilized apatite by a biomimetic coating process using a supersaturated calcium phosphate solution, and then impregnated with S3 via drop-casting. The resulting sponge showed improved bone regeneration in a rat calvarial defect model via enhanced cell infiltration, angiogenesis, osteogenesis, and bone remodeling, while being resorbed by macrophage-mediated processes, highlighting its potential as a bone tissue regeneration scaffold.

学術雑誌論文

Accepted Manuscript

This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1557/s43579-025-00796-9

2159-6859