Functional classification of antineutrophil cytoplasmic antibody (ANCA) and its relation with clinical parameters of ANCA-associated vasculitis

Taniguchi, Mai; Washio, China; Uchizawa, Momo et al.

Biochemistry and Biophysics Reports, 2026, 45, 102428

Permalink : https://hdl.handle.net/2115/98597

このアイテムのアクセス数:74件（2026-08-09 07:33 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
https://doi.org/10.1016/j.bbrep.2025.102428     18

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/98597
タイトル
Functional classification of antineutrophil cytoplasmic antibody (ANCA) and its relation with clinical parameters of ANCA-associated vasculitis
著者
Taniguchi, Mai ; Washio, China ; Uchizawa, Momo ; Ogawa, Naho ; Manabe, Riku ; Arai, Suishin ; Ogawa, Hodaka ; Nishibata, Yuka ; Masuda, Sakiko ; Nakazawa, Daigo ; Tomaru, Utano ; Arimura, Yoshihiro ; Amano, Koichi ; Yuzawa, Yukio ; Sada, Ken-Ei ; Atsumi, Tatsuya ; Dobashi, Hiroaki ; Harigai, Masayoshi ; Matsuo, Seiichi ; Makino, Hirofumi ; Ishizu, A
著者名
Taniguchi, Mai
著者名
Washio, China
著者名
Uchizawa, Momo
著者名
Ogawa, Naho
著者名
Manabe, Riku
著者名
Arai, Suishin
著者名
Ogawa, Hodaka
著者名
Nishibata, Yuka
ORCID
0009-0006-8414-7094
著者名
Masuda, Sakiko
著者名
Nakazawa, Daigo
著者名
Tomaru, Utano
ORCID
0000-0002-6160-1382
著者名
Arimura, Yoshihiro
著者名
Amano, Koichi
著者名
Yuzawa, Yukio
著者名
Sada, Ken-Ei
著者名
Atsumi, Tatsuya
ORCID
0000-0003-2944-5583
著者名
Dobashi, Hiroaki
著者名
Harigai, Masayoshi
著者名
Matsuo, Seiichi
ORCID
0000-0002-1559-3799
著者名
Makino, Hirofumi
ORCID
0000-0002-7084-9734
著者名
Ishizu, A
言語
英語
キーワード
Antineutrophil cytoplasmic antibody (ANCA)
ANCA-associated vasculitis (AAV)
Reactive oxygen species (ROS)
Fcγ receptor (FcγR)
発行日
2026-03
出版者
Elsevier
収録物名
Biochemistry and Biophysics Reports
巻(号)
45
ページ
102428
ページ数
5
抄録
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by serum ANCA and systemic small-vessel vasculitis. Neutrophils are primed to express ANCA antigens on the plasma membrane. ANCA binding to the antigens can transduce signals into neutrophils, releasing reactive oxygen species (ROS) and contributing to AAV development. ANCA-mediated signals are transduced via two pathways: ANCA antigens crosslinked by ANCA, and Fcγ receptor (FcγR), to which the Fc portion of ANCA binds. This study aimed to demonstrate the association of ANCA-mediated neutrophil activation pathways with clinical manifestations of AAV, including renal dysfunction and kidney survival at 6 months after treatment. For this purpose, IgG was extracted from the serum of AAV patients before treatment (n=112), and ROS production from neutrophils exposed to IgG and its suppression by FcγR inhibitors (FcX) were assessed. IgG exhibiting higher ROS production than control IgG was classified as ROS-inducing ANCA and the others as ROS-noninducing ANCA. The former was subclassified into antigen-driven ANCA and FcγR-driven ANCA according to whether the ROS production suppression rate by FcX was <50% or ≧50%, respectively. As a result, ANCA was classified into ROS-inducing antigen-driven ANCA (n=74), ROS-inducing FcγR-driven ANCA (n=22), and ROS-noninducing ANCA (n=16). Serum levels of blood urea nitrogen and creatinine were significantly higher in patients with ROS-inducing FcγR-driven ANCA than in those with ROS-noninducing ANCA. Patients with ROS-inducing FcγR-driven ANCA had a significantly lower kidney survival rate 6 months after treatment than other patients. The collective findings suggest that ROS-inducing FcγR-driven ANCA may predict poor kidney prognosis in AAV.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
EISSN
2405-5808
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1016/j.bbrep.2025.102428