Effect of Acid Suppressants on Adverse Events of ImmuneCheckpoint Inhibitors Using Real-world Databases

Okamoto, Keisuke; Takizawa, Juri; Ueda, Hinata; Narum, Katsuya; Kobayashi, Masaki

Effect of Acid Suppressants on Adverse Events of ImmuneCheckpoint Inhibitors Using Real-world Databases

Okamoto, Keisuke; Takizawa, Juri; Ueda, Hinata et al.

Anticancer Research, 2025, 45(8), 3287-3293

Permalink : https://hdl.handle.net/2115/98829

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アクセス権	open access
URI	https://hdl.handle.net/2115/98829
タイトル	Effect of Acid Suppressants on Adverse Events of ImmuneCheckpoint Inhibitors Using Real-world Databases
著者	Okamoto, Keisuke ; Takizawa, Juri ; Ueda, Hinata ; Narum, Katsuya ; Kobayashi, Masaki
著者名 Okamoto, Keisuke
著者名 Takizawa, Juri
著者名 Ueda, Hinata
著者名 Narum, Katsuya
著者名 Kobayashi, Masaki
言語	英語
キーワード	Immune checkpoint inhibitor
	acid suppressants
	immune-related adverse events
	proton pump inhibitor
	real-world adverse events database
発行日	2025-08-01
出版者	International Institute of Anticancer Research
収録物名	Anticancer Research
巻(号)	45(8)
ページ	3287-3293
抄録	Background/Aim: Immune checkpoint inhibitors (ICIs) cause immune-related adverse events (irAEs) in variousorgans. Although many studies have suggested that acid suppressants (ASs) may affect irAEs, limited sample sizeshave hindered detailed evaluations. Therefore, this study aimed to assess the impact of ASs on individual irAEs usinglarge real-world databases, the Japanese Adverse Drug Event Report database (JADER) and the U.S. Food and DrugAdministration Adverse Event Reporting System (FAERS). Materials and Methods: We analyzed adverse event (AE) reports from the JADER and FAERS databases to assess theimpact of ASs on ICI-related AEs. Reporting odds ratios (RORs) and 95% confidence intervals (95%CI) werecalculated. Drug-drug interaction signals were defined by non-overlapping 95%CIs between ICIs alone and theircombination use. Results: Co-administration with ASs or proton pump inhibitors (PPIs) was associated with an increased risk of acutekidney injury (AKI) in both datasets, while H2-receptor antagonists (H2RAs) showed weaker or no signals. Theincidence of endocrine-related AEs tended to decrease with ASs. The colitis results differed between the two datasets,with a decreased incidence in the JADER and an increased incidence in FAERS. Other ICI-related AEs showedconsistent trends across datasets. Subgroup analyses of individual PPIs revealed varying results for AKI and colitisbetween the JADER and FAERS databases, with no consistent trends across PPIs. Conclusion: ASs have diverse effects on ICI-induced AEs and their characteristics may differ between PPIs and H2RAs
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0250-7005
EISSN	1791-7530
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.21873/anticanres.17689