Epidemiological, clinical, and virological characterizations of Yezo virus infections, an emerging tick-borne orthonairovirus disease in Japan

Yamaguchi, Hiroki; Mizuma, Keita; Watari, Kei; Ohari, Yuma; Mitsuhashi, Kazuya; Tamiya, Kazuma; Kawaguchi, Nijiho; Orba, Yasuko; Saijo, Masayuki; Matsuno, Keita

Epidemiological, clinical, and virological characterizations of Yezo virus infections, an emerging tick-borne orthonairovirus disease in Japan

Yamaguchi, Hiroki; Mizuma, Keita; Watari, Kei et al.

The Journal of Infectious Diseases, 2026, jiag073

Permalink : https://hdl.handle.net/2115/98831

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/98831
タイトル	Epidemiological, clinical, and virological characterizations of Yezo virus infections, an emerging tick-borne orthonairovirus disease in Japan
著者	Yamaguchi, Hiroki ; Mizuma, Keita ; Watari, Kei ; Ohari, Yuma ; Mitsuhashi, Kazuya ; Tamiya, Kazuma ; Kawaguchi, Nijiho ; Orba, Yasuko ; Saijo, Masayuki ; Matsuno, Keita
著者名 Yamaguchi, Hiroki
著者名 Mizuma, Keita
著者名 Watari, Kei
著者名 Ohari, Yuma
著者名 Mitsuhashi, Kazuya
著者名 Tamiya, Kazuma
著者名 Kawaguchi, Nijiho
著者名 Orba, Yasuko
著者名 Saijo, Masayuki
著者名 Matsuno, Keita
言語	英語
キーワード	tick-borne virus
	arbovirus
	emerging infectious diseases
発行日	2026-02-10
出版者	Oxford University Press
収録物名	The Journal of Infectious Diseases
ページ	jiag073
抄録	Background Febrile disease caused by infections of Yezo virus (YEZV), a tick-borne orthonairovirus, was first reported in Japan in 2021 and subsequently identified in China. While the recent studies suggest a broader endemic area of the emerging YEZV infections, its clinical and epidemiological characteristics remain poorly elucidated due to the limited number of reported cases. Methods We conducted retrospective and prospective surveillance of patients with suspected tick-borne febrile illnesses in Hokkaido, Japan, between 2013 and 2024. Serum samples were analyzed by RT-qPCR, IgM/IgG ELISA, and neutralization assay. Viral genome of isolates was sequenced and phylogenetically analyzed with publicly available YEZV genomes. Results A total of 22 patients with YEZV infections including 10 newly identified patients was analyzed. Most infections occurred between May and July, coinciding with the peak activity of Ixodes ticks in the study area. A case from southern Hokkaido was firstly identified. Fever, leukocytopenia, thrombocytopenia, elevated levels of liver enzymes, and ferritin were determined as common features observed in patients with YEZV infections. Viral RNA was typically detectable in the serum within 7 days after the disease onset. Serum antibodies became positive later and might persist up to at least 600 days. Phylogenetic analysis incorporating five new isolates showed the circulations of two genetic groups of YEZVs in Japan. Conclusions Our results revealed characteristics of YEZV infections in patients and highlighted the importance of combination of molecular and serological diagnostics. The proposed case definitions and diagnostic framework may contribute future surveillance.
資源タイプ	学術雑誌論文
出版タイプ	Author's Original
権利情報	This article has been accepted for publication in The Journal of Infectious Diseases Published by Oxford University Press.
PISSN	0022-1899
EISSN	1537-6613
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/infdis/jiag073