Therapeutic Courses of Presumed Intracranial Immature Teratoma Diagnosed Based on Increased Alpha-Fetoprotein

Yamaguchi, Shigeru; Ishi, Yukitomo; Okamoto, Michinari; Oki, Sogo; Sawaya, Ryosuke; Motegi, Hiroaki; Terashita, Yukayo; Hirabayashi, Shinsuke; Nishioka, Kentaro; Hashimoto, Takayuki; Okada, Hiromi; Takakuwa, Emi; Aoyama, Hidefumi; Manabe, Atsushi; Fujimura, Miki

Therapeutic Courses of Presumed Intracranial Immature Teratoma Diagnosed Based on Increased Alpha-Fetoprotein

Yamaguchi, Shigeru; Ishi, Yukitomo; Okamoto, Michinari et al.

Journal of Child Neurology, 2026

Permalink : https://hdl.handle.net/2115/99880

このアイテムのアクセス数:62件（2026-08-24 13:14 集計）

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アクセス権	open access
URI	https://hdl.handle.net/2115/99880
タイトル	Therapeutic Courses of Presumed Intracranial Immature Teratoma Diagnosed Based on Increased Alpha-Fetoprotein
著者	Yamaguchi, Shigeru ; Ishi, Yukitomo ; Okamoto, Michinari ; Oki, Sogo ; Sawaya, Ryosuke ; Motegi, Hiroaki ; Terashita, Yukayo ; Hirabayashi, Shinsuke ; Nishioka, Kentaro ; Hashimoto, Takayuki ; Okada, Hiromi ; Takakuwa, Emi ; Aoyama, Hidefumi ; Manabe, Atsushi ; Fujimura, Miki
e-Rad_Researcher 70399939 著者名 Yamaguchi, Shigeru
e-Rad_Researcher 30812284 著者名 Ishi, Yukitomo
e-Rad_Researcher 10970915 著者名 Okamoto, Michinari
著者名 Oki, Sogo
著者名 Sawaya, Ryosuke
e-Rad_Researcher 40748844 著者名 Motegi, Hiroaki
e-Rad_Researcher 20832702 著者名 Terashita, Yukayo
e-Rad_Researcher 50769635 著者名 Hirabayashi, Shinsuke
e-Rad_Researcher 80463743 著者名 Nishioka, Kentaro
e-Rad_Researcher 60400678 著者名 Hashimoto, Takayuki
著者名 Okada, Hiromi
著者名 Takakuwa, Emi
e-Rad_Researcher 80360915 著者名 Aoyama, Hidefumi
e-Rad_Researcher 20292849 著者名 Manabe, Atsushi
e-Rad_Researcher 00361098 著者名 Fujimura, Miki
言語	英語
キーワード	alpha-fetoprotein
	growing teratoma syndrome
	immature teratoma
	intracranial germ cell tumor
	teratoma
発行日	2026-05-07
出版者	SAGE Publications
収録物名	Journal of Child Neurology
抄録	Intracranial immature teratoma (ImT) is one of the non-germinomatous germ cell tumors, and elevated serum alpha-fetoprotein (AFP) value is a crucial clinical diagnostic indicator of ImT. In this retrospective study conducted among patients diagnosed with intracranial ImT, diagnostic procedures, therapeutic courses, histopathologic diagnosis, and prognosis were reviewed. Among 106 patients with intracranial germ cell tumors, 11 were diagnosed with ImT and treated since 2000. ImT was diagnosed via biopsy or based on mild or moderate serum AFP elevation of 10-500 ng/mL. Complete remission via chemoradiotherapy was achieved in only 2 patients (18%); 5 patients (45%) suffered from growing disease during treatment; and 7 patients required salvage tumor resection. The 10-year progression-free and overall survival rates were 76.2% and 87.5%, respectively. The therapeutic courses of ImT varied. Notably, cases in which treatment was applied considering ImT were highly prone to experience growing disease during treatment.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Yamaguchi S, Ishi Y, Okamoto M, et al, Therapeutic Courses of Presumed Intracranial Immature Teratoma Diagnosed Based on Increased Alpha-Fetoprotein, Journal of Child Neurology. Copyright © 2026, The Author(s). DOI: 10.1177/08830738261446144.
PISSN	0883-0738
EISSN	1708-8283
関連情報	PMID 42095539
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1177/08830738261446144