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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Dental Medicine / Faculty of Dental Medicine >
Peer-reviewed Journal Articles, etc >
Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs
| Title: | Influence of Root Dentin Surface Conditioning with Bone Morphogenetic Protein-2 on Periodontal Wound Healing in Beagle Dogs |
| Authors: | MIYAJI, Hirofumi1 Browse this author →KAKEN DB | | SUGAYA, Tsutomu2 Browse this author →KAKEN DB | | IBE, Keisuke3 Browse this author | | ISHIZUKA, Ryousuke4 Browse this author | | TOKUNAGA, Keisuke5 Browse this author | | KAWANAMI, Masamitsu6 Browse this author →KAKEN DB |
| Authors(alt): | MIYAJI, Hirofumi1 | | SUGAYA, Tsutomu2 | | IBE, Keisuke3 | | ISHIZUKA, Ryousuke4 | | TOKUNAGA, Keisuke5 | | KAWANAMI, Masamitsu6 |
| Keywords: | bone morphogenetic protein-2 | | root dentin surface conditioning | | periodontal wound healing | | dog |
| Issue Date: | 30-Mar-2011 |
| Publisher: | Japanese Association of Regenerative Dentistry | | 日本再生歯科医学会 |
| Journal Title: | Journal of Oral Tissue Engineering |
| Volume: | 8 |
| Issue: | 3 |
| Start Page: | 173 |
| End Page: | 180 |
| Publisher DOI: | 10.11223/jarde.8.173 |
| Abstract: | Bone morphogenetic protein-2 (BMP-2) may play a major role in osteoinduction and osteoclast differentiation. The influence of BMP-2 conditioning in graded doses to root dentin surface on periodontal wound healing was examined.Twenty-four periodontal defects were surgically created on the buccal roots of four beagle dogs. The denuded root dentin surfaces were demineralized with 24% EDTA, 0.1 and 1.0 μg/μL BMP-2 solution (15 μL) was applied, and the groups were labeled as low-dose BMP (BL) and high-dose BMP (BH), respectively. In the control roots, phosphate-buffered saline was applied to the root surface. Specimens were histologically analyzed 16 weeks after surgery.Periodontal wound healing was stimulated by conditioning with BMP-2. Formation of alveolar bone and cementum-like tissue was observed; however, in BH group, ankylosis and root resorption were accelerated in the defect area, and there was little evidence of periodontal ligament formation between alveolar bone and root surface. |
| Rights: | 日本再生歯科医学会(利用は著作権の範囲内に限られます) |
| Type: | article |
| URI: | http://hdl.handle.net/2115/59873 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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