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Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins
Title: | Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins |
Authors: | Taru, Hidenori Browse this author →KAKEN DB | Suzuki, Toshiharu Browse this author | Bissette, Garth Browse this author |
Issue Date: | 26-Aug-2009 |
Publisher: | IOS Press |
Journal Title: | Journal of Alzheimer's Disease |
Volume: | 18 |
Issue: | 2 |
Start Page: | 253 |
End Page: | 265 |
Publisher DOI: | 10.3233/JAD-2009-1148 |
PMID: | 19584434 |
Abstract: | β-Amyloid precursor protein (APP) is a receptor-like, type-I membrane protein that plays a central role in the pathogenesis of Alzheimer’s disease. The cytoplasmic domain of APP is important for the metabolism and physiological functions of APP. The cytoplasmic domain contains a GYENPTY motif that interacts with proteins that contain a phosphotyrosine binding (PTB) domain such as X11/Mint, FE65, and the JIP family of proteins. X11 and X11-like proteins are neuronal adaptor proteins involved in presynaptic function and the intracellular trafficking of proteins. Recent studies in X11s knock-out mice confirmed findings from in vitro studies that X11 proteins affect APP metabolism and the generation of β-amyloid peptide. FE65 proteins are involved in transactivation in coordination with the intracellular domain fragment of APP, and/or in cellular responses to DNA damage. Neurodevelopmental defects observed in FE65s double knockout mice suggest that FE65 proteins cooperate with APP to play a role in neuronal cytoskeletal regulation. c-Jun N-terminal kinase (JNK) interacting protein-1 (JIP-1), a scaffolding protein for the JNK kinase cascade, has been suggested to mediate the intracellular trafficking of APP by molecular motor kinesin-1. This article reviews some of the recent findings regarding the regulation of physiological function and metabolism of APP by APP binding proteins. |
Rights: | The final publication is available at IOS Press through
http://dx.doi.org/10.3233/JAD-2009-1148 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/66563 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 多留 偉功
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