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Recent SubmissionsIkeda, Kazuki... [et al.] (2023) Formation of Isolable Dearomatized [4+2] Cycloadducts from Benzenes, Naphthalenes, and N-Heterocycles Using 1,2-Dihydro-1,2,4,5-tetrazine-3,6-diones as Arenophiles under Visible Light Irradiation. Journal of the American Chemical Society, 145(16): 9326-9333 We report that the dearomative [4 + 2] cycloaddition between 1,2-dihydro-1,2,4,5-tetrazine-3,6-dione....
Yoshimura, Aya... [et al.] (2024) Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber. Chemical and pharmaceutical bulletin, 72(1): 80-85 Five new viridogriseins B-F were isolated from Streptomyces niveoruber, along with viridogrisein and....
Tomita, Eiki... [et al.] (2023) An Electron-Deficient Cp-E Iridium(III) Catalyst: Synthesis, Characterization, and Application to Ether-Directed C-H Amidation. Angewandte chemie-international edition, 62(21): e202301259 The synthesis, characterization, and catalytic performance of an iridium(III) catalyst with an elect....
Honda, Keiko... [et al.] (2023) Accumulation of amyloid-,B in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging, 123: 63-74 Apolipoprotein E4 (apoE4) is a risk factor for Alzheimer's disease (AD). Here, we investigated brain....
Isoda, Kaho... [et al.] (2023) Cobalt(I)-Catalyzed Reductive Cyclization of Enynes and Diynes Using Hydrogen Gas as a Reductant. Organic letters, 25(12): 2103-2107 Reductive cyclization of enynes and diynes by using H2 gas as a reductant was realized, and the corr....
Tamura, Yuka... [et al.] (2023) Incomplete Elongation of Ultra-long-chain Polyunsaturated Acyl-CoAs by the Fatty Acid Elongase ELOVL4 in Spinocerebellar Ataxia Type 34. Molecular and cellular biology, 43(2): 85-101 Spinocerebellar ataxias (SCAs) are autosomal dominant diseases characterized by cerebellar atrophy a....
Kaguchi, Rintaro... [et al.] (2023) Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry. Journal of the American Chemical Society, 145(6): 3665-3681 Peptides can be converted to highly active compounds by introducing appropriate substituents on the ....
Komatani, Yuya... [et al.] (2023) Solid-Phase Total Synthesis of Sandramycin and Its Analogues. Organic letters, 25(3): 543-548 Solid-phase total synthesis of sandramycin (1), which is a C2-symmetric cyclic decadepsipeptide natu....
Wakikawa, Takumi... [et al.] (2022) Native Amide-Directed C(sp3)−H Amidation Enabled by Electron-Deficient RhIII Catalyst and Electron-Deficient 2-Pyridone Ligand. Angewandte chemie-international edition, 61(52): e202213659 Trivalent group-9 metal catalysts with a cyclopentadienyl-type ligand (CpMIII; M=Co, Rh, Ir, Cp=cycl....
Saito, Yoshitaka... [et al.] (2022) Risk factor analysis for regorafenib-induced severe hypertension in metastatic colorectal cancer treatment. Supportive care in cancer, 30: 10203-10211 Regorafenib, a multikinase inhibitor, is effective in treating metastatic colorectal cancer (mCRC). ....
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