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Solid-Phase Total Synthesis of Sandramycin and Its Analogues

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Title: Solid-Phase Total Synthesis of Sandramycin and Its Analogues
Authors: Komatani, Yuya Browse this author
Momosaki, Kyoka Browse this author
Katsuyama, Akira Browse this author →KAKEN DB
Yamamoto, Kazuki Browse this author
Kaguchi, Rintaro Browse this author
Ichikawa, Satoshi Browse this author →KAKEN DB
Issue Date: 18-Jan-2023
Publisher: American Chemical Society
Journal Title: Organic letters
Volume: 25
Issue: 3
Start Page: 543
End Page: 548
Publisher DOI: 10.1021/acs.orglett.2c04327
Abstract: Solid-phase total synthesis of sandramycin (1), which is a C2-symmetric cyclic decadepsipeptide natural product, and its analogues is described. On-resin ester formation and [5+5] peptide coupling allowed the preparation of a range of desymmetrized analogues. An amino acid residue that would not hamper the biological activity of 1 was successfully identified, and probe molecules and dimeric analogues were prepared on the basis of the result of the structure-activity relationship study.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 勝山 彬

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