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Solid-Phase Total Synthesis of Sandramycin and Its Analogues
| Title: | Solid-Phase Total Synthesis of Sandramycin and Its Analogues |
| Authors: | Komatani, Yuya Browse this author | | Momosaki, Kyoka Browse this author | | Katsuyama, Akira Browse this author →KAKEN DB | | Yamamoto, Kazuki Browse this author | | Kaguchi, Rintaro Browse this author | | Ichikawa, Satoshi Browse this author →KAKEN DB |
| Issue Date: | 18-Jan-2023 |
| Publisher: | American Chemical Society |
| Journal Title: | Organic letters |
| Volume: | 25 |
| Issue: | 3 |
| Start Page: | 543 |
| End Page: | 548 |
| Publisher DOI: | 10.1021/acs.orglett.2c04327 |
| Abstract: | Solid-phase total synthesis of sandramycin (1), which is a C2-symmetric cyclic decadepsipeptide natural product, and its analogues is described. On-resin ester formation and [5+5] peptide coupling allowed the preparation of a range of desymmetrized analogues. An amino acid residue that would not hamper the biological activity of 1 was successfully identified, and probe molecules and dimeric analogues were prepared on the basis of the result of the structure-activity relationship study. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-UJZNIRYD6IYBD5B6YGMY. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/91297 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 勝山 彬
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