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Hokkaido University Collection of Scholarly and Academic Papers >
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Recent SubmissionsTaru, Hidenori... [et al.] (2009) Regulation of the Physiological Function and Metabolism of AβPP by AβPP Binding Proteins. Journal of Alzheimer's Disease, 18(2): 253-265 β-Amyloid precursor protein (APP) is a receptor-like, type-I membrane protein that
plays a central ....
Xu, Yan... [et al.] (2015) SYD-1C, UNC-40 (DCC) and SAX-3 (Robo) function interdependently to promote axon guidance by regulating the MIG-2 GTPase. PLoS genetics, 11(4): e1005185 During development, axons must integrate directional information encoded by multiple guidance cues a....
Kamiya, Hiroyuki... [et al.] (2017) Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex. Nucleosides, nucleotides & nucleic acids, 35(7): 379-388 A 5-tailed duplex (TD) DNA corrects a base-substitution mutation. In this study, the effects of inse....
Yamada, Yuma... [et al.] (2015) Hyaluronic acid controls the uptake pathway and intracellular trafficking of an octaarginine-modified gene vector in CD44 positive- and CD44 negative-cells. Biomaterials, 52: 189-198 The cellular uptake pathway for a gene vector is an important factor in transgene expression. We pre....
Furukawa, Ryo... [et al.] (2015) Mitochondrial delivery of antisense RNA by MITO-Porter results in mitochondrial RNA knockdown, and has a functional impact on mitochondria. Biomaterials, 57: 107-115 Mitochondrial genome-targeting nucleic acids are promising therapeutic candidates for treating mitoc....
Naganuma, Tatsuro... [et al.] (2016) Disruption of the Sjogren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery. Journal of Biological Chemistry (JBC), 291(22): 11676-11688 The fatty aldehyde dehydrogenase (FALDH) ALDH3A2 is the causative gene of Sjogren Larsson syndrome (....
Mita, Tsuyoshi... [et al.] (2016) Stereoretentive Addition of N-tert-Butylsulfonyl-alpha-Amido Silanes to Aldehydes, Ketones, alpha,beta-Unsaturated Esters, and Imines. Chemistry-an asian journal, 11(10): 1528-1531 Enantioenriched N-tert-butylsulfonyl-alpha-amido si-lanes were successfully reacted with aldehydes, ....
Togi, Sumihito... [et al.] (2016) A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3. Journal of Biological Chemistry (JBC), 291(21): 11161-11171 Signal transducer and activator of transcription 3 (STAT3) is involved in cell proliferation, differ....
Sato, Yusuke... [et al.] (2016) Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery. Journal of controlled release, 229: 48-57 Because nanoparticles with diameters less than 50 nm penetrate stromal-rich tumor tissues more effic....
Yamada, Yuma... [et al.] (2016) A Dual-Ligand Liposomal System Composed of a Cell-Penetrating Peptide and a Mitochondrial RNA Aptamer Synergistically Facilitates Cellular Uptake and Mitochondrial Targeting. Journal of Pharmaceutical Sciences, 105(5): 1705-1713 It has been reported that the use of mitochondrial RNA aptamers including RNase P (RP) results in th....
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