|
Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >
Synthesis of 2,3-Disubstituted Indoles by Nickel(0)-Catalyzed Migratory Cycloisomerization of o-Alkynylanilides
| Title: | Synthesis of 2,3-Disubstituted Indoles by Nickel(0)-Catalyzed Migratory Cycloisomerization of o-Alkynylanilides |
| Authors: | Koshiba, Mikiko Browse this author | | Furuki, Yuto Browse this author | | Morisaki, Kazuhiro Browse this author | | Doi, Ryohei Browse this author | | Sato, Yoshihiro Browse this author →KAKEN DB |
| Keywords: | Cycloisomerization | | Indole | | Migration | | NHC | | Nickel |
| Issue Date: | 5-Jun-2023 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Asian journal of organic chemistry |
| Volume: | 12 |
| Issue: | 7 |
| Start Page: | e202300272 |
| Publisher DOI: | 10.1002/ajoc.202300272 |
| Abstract: | We herein report a nickel-catalyzed migratory cycloisomerization of o-alkynylanilides, giving 2,3-disubstituted indoles in good yields. The cyclization proceeded via acyl transfer on the nitrogen atom of the substrate to C3-position in the product, and an N-heterocyclic carbene (NHC) ligand such as ICy or SICy was found to be suitable in this reaction. It was thought that the reaction proceeds via an aza-nickelcyclepentene intermediate formed from alkyne and the C=O bond of the amide moiety in o-alkynylanilides. |
| Rights: | This is the pre-peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/10.1002/ajoc.202300272, which has been published in final form at 10.1002/ajoc.202300272. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92586 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 佐藤 美洋
|
