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Synthesis of Benzo[c]azepine-1,3(2H)-diones via C−H Alkylation/Cyclization with α,β-Unsaturated Acyl Fluorides
| Title: | Synthesis of Benzo[c]azepine-1,3(2H)-diones via C−H Alkylation/Cyclization with α,β-Unsaturated Acyl Fluorides |
| Authors: | Hosoi, Satoko Browse this author | | Hirata, Yuki Browse this author | | Kurihara, Takumaru Browse this author | | Kojima, Masahiro Browse this author →KAKEN DB | | Yoshino, Tatsuhiko Browse this author →KAKEN DB | | Matsunaga, Shigeki Browse this author →KAKEN DB |
| Keywords: | benzo[c]azepine-1,3(2H)-dione | | C-H activation | | α,β-unsaturated acyl fluoride | | hydroxamate imide |
| Issue Date: | 17-May-2023 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Asian journal of organic chemistry |
| Volume: | 12 |
| Issue: | 8 |
| Start Page: | e202300218 |
| Publisher DOI: | 10.1002/ajoc.202300218 |
| Abstract: | Transition-metal-catalyzed directed C-H functionalization reactions are a powerful method to construct N-heterocycles. However, compared to the formation of five- and six-membered rings, that of seven-membered rings has been much less explored. Here, the synthesis of benzo[c]azepine-1,3(2H)-diones is described, which are benzene-fused seven-membered imides, from hydroxamates and α,β-unsaturated acyl fluorides via C-H activation using a Cp*Rh(III) catalyst. Under mild reaction conditions, this reaction affords benzo[c]azepine-1,3(2H)-diones that bear a substituent at the 5-position. |
| Rights: | This is the pre-peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/10.1002/ajoc.202300218, which has been published in final form at 10.1002/ajoc.202300218. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92583 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉野 達彦
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