HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

An Electron-Deficient Cp-E Iridium(III) Catalyst: Synthesis, Characterization, and Application to Ether-Directed C-H Amidation

Files in This Item:
manuscript_R2_edited.pdf830.32 kBPDFView/Open
Please use this identifier to cite or link to this item:

Title: An Electron-Deficient Cp-E Iridium(III) Catalyst: Synthesis, Characterization, and Application to Ether-Directed C-H Amidation
Authors: Tomita, Eiki Browse this author
Kojima, Masahiro Browse this author →KAKEN DB
Nagashima, Yuki Browse this author
Tanaka, Ken Browse this author
Sugiyama, Haruki Browse this author
Segawa, Yasutomo Browse this author
Furukawa, Atsushi Browse this author
Maenaka, Katsumi Browse this author →KAKEN DB
Maeda, Satoshi Browse this author →KAKEN DB
Yoshino, Tatsuhiko Browse this author →KAKEN DB
Matsunaga, Shigeki Browse this author →KAKEN DB
Keywords: Amidation
C-H Activation
Cp-E Ligand
Ether Directing Group
Issue Date: 14-Mar-2023
Publisher: Wiley-Blackwell
Journal Title: Angewandte chemie-international edition
Volume: 62
Issue: 21
Start Page: e202301259
Publisher DOI: 10.1002/anie.202301259
Abstract: The synthesis, characterization, and catalytic performance of an iridium(III) catalyst with an electron-deficient cyclopentadienyl ligand ([(CpIrI2)-Ir-E](2)) are reported. The [(CpIrI2)-Ir-E](2) catalyst was synthesized by complexation of a precursor of the Cp-E ligand with [Ir(cod)OAc](2), followed by oxidation, desilylation, and removal of the COD ligand. The electron-deficient [(CpIrI2)-Ir-E](2) catalyst enabled C-H amidation reactions assisted by a weakly coordinating ether directing group. Experimental mechanistic studies and DFT calculations suggested that the high catalytic performance of [(CpIrI2)-Ir-E](2) is due to its electron-deficient nature, which accelerates both C-H activation and Ir-V-nitrenoid formation.
Rights: This is the peer reviewed version of the following article:, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉野 達彦

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University