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Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber

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Title: Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber
Authors: Yoshimura, Aya Browse this author →KAKEN DB
Honda, Takumi Browse this author
Wakimoto, Toshiyuki Browse this author →KAKEN DB
Keywords: viridogrisein
self-resistant system
Issue Date: 18-Jan-2024
Publisher: The Pharmaceutical Society of Japan
Journal Title: Chemical and pharmaceutical bulletin
Volume: 72
Issue: 1
Start Page: 80
End Page: 85
Publisher DOI: 10.1248/cpb.c23-00776
Abstract: Five new viridogriseins B-F were isolated from Streptomyces niveoruber, along with viridogrisein and griseoviridin which belong to streptogramin family antibiotics. A combination of liquid chromatographytandem mass spectrometry (LC-MS/MS) analysis and the advanced Marfey's method elucidated the structures of viridogriseins B-F, each featuring distinct constituent amino acids. Consistent with other streptogramin family antibiotics, these viridogrisein analogs exhibited potent antibacterial activity against Staphylococcus aureus. Furthermore, equimolar mixtures of each viridogrisein analog and griseoviridin inhibited the growth of S. aureus more potently than each analog treatment alone. Finally, an in vitro functional analysis of SgvY, encoded in the viridogrisein biosynthetic gene cluster, revealed that SgvY detoxifies viridogrisein against S. aureus by linearization. Considering that viridogrisein is not autotoxic to S. niveoruber, SgvY likely contributes to the self -resistance system against viridogrisein in S. niveoruber.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 吉村 彩

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