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Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber
| Title: | Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from Streptomyces niveoruber |
| Authors: | Yoshimura, Aya Browse this author →KAKEN DB | | Honda, Takumi Browse this author | | Wakimoto, Toshiyuki Browse this author →KAKEN DB |
| Keywords: | viridogrisein | | antibiotic | | biosynthesis | | depsipeptide | | streptogramin | | self-resistant system |
| Issue Date: | 18-Jan-2024 |
| Publisher: | The Pharmaceutical Society of Japan |
| Journal Title: | Chemical and pharmaceutical bulletin |
| Volume: | 72 |
| Issue: | 1 |
| Start Page: | 80 |
| End Page: | 85 |
| Publisher DOI: | 10.1248/cpb.c23-00776 |
| Abstract: | Five new viridogriseins B-F were isolated from Streptomyces niveoruber, along with viridogrisein and griseoviridin which belong to streptogramin family antibiotics. A combination of liquid chromatographytandem mass spectrometry (LC-MS/MS) analysis and the advanced Marfey's method elucidated the structures of viridogriseins B-F, each featuring distinct constituent amino acids. Consistent with other streptogramin family antibiotics, these viridogrisein analogs exhibited potent antibacterial activity against Staphylococcus aureus. Furthermore, equimolar mixtures of each viridogrisein analog and griseoviridin inhibited the growth of S. aureus more potently than each analog treatment alone. Finally, an in vitro functional analysis of SgvY, encoded in the viridogrisein biosynthetic gene cluster, revealed that SgvY detoxifies viridogrisein against S. aureus by linearization. Considering that viridogrisein is not autotoxic to S. niveoruber, SgvY likely contributes to the self -resistance system against viridogrisein in S. niveoruber. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/92020 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 吉村 彩
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