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Cobalt(I)-Catalyzed Reductive Cyclization of Enynes and Diynes Using Hydrogen Gas as a Reductant
| Title: | Cobalt(I)-Catalyzed Reductive Cyclization of Enynes and Diynes Using Hydrogen Gas as a Reductant |
| Authors: | Isoda, Kaho Browse this author | | Sato, Yoshihiro Browse this author →KAKEN DB |
| Issue Date: | 31-Mar-2023 |
| Publisher: | American Chemical Society |
| Journal Title: | Organic letters |
| Volume: | 25 |
| Issue: | 12 |
| Start Page: | 2103 |
| End Page: | 2107 |
| Publisher DOI: | 10.1021/acs.orglett.3c00524 |
| Abstract: | Reductive cyclization of enynes and diynes by using H2 gas as a reductant was realized, and the corresponding cyclized products were obtained in good yields without olefin isomerization and over-reduction of the products. By an experiment using D2 instead of H2, it was confirmed that H2 unambiguously operates as a reductant in this reaction. The protocol of the reaction is very economical and user-friendly, using air-and moisture-stable CoBr2 center dot 6H2O and 1 atm of pressure of H2. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-RR5P3TD2XX2QE749UHM7. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/91879 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐藤 美洋
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