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Cobalt(I)-Catalyzed Reductive Cyclization of Enynes and Diynes Using Hydrogen Gas as a Reductant

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Title: Cobalt(I)-Catalyzed Reductive Cyclization of Enynes and Diynes Using Hydrogen Gas as a Reductant
Authors: Isoda, Kaho Browse this author
Sato, Yoshihiro Browse this author →KAKEN DB
Issue Date: 31-Mar-2023
Publisher: American Chemical Society
Journal Title: Organic letters
Volume: 25
Issue: 12
Start Page: 2103
End Page: 2107
Publisher DOI: 10.1021/acs.orglett.3c00524
Abstract: Reductive cyclization of enynes and diynes by using H2 gas as a reductant was realized, and the corresponding cyclized products were obtained in good yields without olefin isomerization and over-reduction of the products. By an experiment using D2 instead of H2, it was confirmed that H2 unambiguously operates as a reductant in this reaction. The protocol of the reaction is very economical and user-friendly, using air-and moisture-stable CoBr2 center dot 6H2O and 1 atm of pressure of H2.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 美洋

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