Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.

Asahina, Hajime; Yamazaki, Koichi; Kinoshita, Ichiro; Yokouchi, Hiroshi; Dosaka-Akita, Hirotoshi; Nishimura, Masaharu

Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.

Asahina, Hajime; Yamazaki, Koichi; Kinoshita, Ichiro et al.

Lung Cancer, 2006, 54(3), 419-422

Permalink : https://hdl.handle.net/2115/17005

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アクセス権	open access
URI	https://hdl.handle.net/2115/17005
タイトル	Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
著者	Asahina, Hajime ; Yamazaki, Koichi ; Kinoshita, Ichiro ; Yokouchi, Hiroshi ; Dosaka-Akita, Hirotoshi ; Nishimura, Masaharu
著者名 Asahina, Hajime
著者名 Yamazaki, Koichi
著者名 Kinoshita, Ichiro
著者名 Yokouchi, Hiroshi
著者名 Dosaka-Akita, Hirotoshi
著者名 Nishimura, Masaharu
言語	英語
キーワード	Epidermal growth factor receptor (EGFR)
	Mutation
	Non-small cell lung cancer (NSCLC)
	Gefitinib
	Chemotherapy
	First-line therapy
発行日	2006-12
出版者	Elsevier
収録物名	Lung Cancer
巻(号)	54(3)
ページ	419-422
抄録	Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) are associated with clinical responsiveness to EGFR-tyrosine kinase inhibitors (EGFR-TKIs) in patients with non-small cell lung cancers (NSCLCs). However, certain rare EGFR mutations including S768I are reported to confer less in vitro sensitivity to gefitinib, an EGFR-TKI, than major mutations such as exon 19 deletions and L858R and even the wild-type counterpart. Here, we report the first case of adenocarcinoma of the lung in which the patient had rare mutations S768I and V769L and was treated with gefitinib. Disease progressed during 6 weeks of treatment. This case suggests that in vitro sensitivity to gefitinib correlates with distinct clinical responsiveness to gefitinib in various types of EGFR mutations.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0169-5002
関連情報	PMID 17045698
関連情報	URI http://www.sciencedirect.com/science/journal/01695002
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.lungcan.2006.09.005