Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation

Yokoi, Masahiko; Yamagishi, Sho-ichi; Takeuchi, Masayoshi; Matsui, Takanori; Yoshida, Yumiko; Ohgami, Kazuhiro; Amano-Okamoto, Tamami; Ohno, Shigeaki

Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation

Yokoi, Masahiko; Yamagishi, Sho-ichi; Takeuchi, Masayoshi et al.

British Journal of Ophthalmology, 2007, 91(3), 397-398

Permalink : https://hdl.handle.net/2115/20277

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アクセス権	open access
URI	https://hdl.handle.net/2115/20277
タイトル	Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation
著者	Yokoi, Masahiko ; Yamagishi, Sho-ichi ; Takeuchi, Masayoshi ; Matsui, Takanori ; Yoshida, Yumiko ; Ohgami, Kazuhiro ; Amano-Okamoto, Tamami ; Ohno, Shigeaki
著者名 Yokoi, Masahiko
著者名 Yamagishi, Sho-ichi
著者名 Takeuchi, Masayoshi
著者名 Matsui, Takanori
著者名 Yoshida, Yumiko
著者名 Ohgami, Kazuhiro
著者名 Amano-Okamoto, Tamami
著者名 Ohno, Shigeaki
言語	英語
発行日	2007-03
出版者	BMJ Publishing Group
収録物名	British Journal of Ophthalmology
巻(号)	91(3)
ページ	397-398
抄録	We investigated whether vitreous levels of advanced glycation end products (AGEs) were positively correlated with vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy patients sufficiently treated with retinal photocoagulation. Vitreous AGE and VEGF levels were significantly higher in patients with diabetes than in controls. Positive correlation between AGE and VEGF was found in patients with diabetic retinopathy sufficiently treated with retinal photocoagulation (r = 0.44, p<0.05), but not in those who were insufficiently treated (r = 0.26, p = 0.18). The present observations suggest that AGE may induce VEGF expression in an ischaemia-independent mechanism. AGE could be one of the important determinants of VEGF in diabetic retinopathy without obvious ischaemic regions.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0007-1161
関連情報	PMID 17322470
関連情報	URI http://www.bmj.com/
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1136/bjo.2006.100198