Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60

Hosokawa, Masashi; Wanezaki, Satoshi; Miyauchi, Kozue; Kurihara, Hideyuki; Kohno, Hiroyuki; Kawabata, Jun; Odashima, Shizuo; Takahashi, Koretaro

Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60

Hosokawa, Masashi; Wanezaki, Satoshi; Miyauchi, Kozue et al.

Food Science and Technology Research, 1999, 5(3), 243-246

Permalink : https://hdl.handle.net/2115/42695

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アクセス権	open access
URI	https://hdl.handle.net/2115/42695
タイトル	Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60
著者	Hosokawa, Masashi ; Wanezaki, Satoshi ; Miyauchi, Kozue ; Kurihara, Hideyuki ; Kohno, Hiroyuki ; Kawabata, Jun ; Odashima, Shizuo ; Takahashi, Koretaro
e-Rad_Researcher 10241374 著者名 Hosokawa, Masashi
著者名 Wanezaki, Satoshi
著者名 Miyauchi, Kozue
e-Rad_Researcher 40234570 著者名 Kurihara, Hideyuki
著者名 Kohno, Hiroyuki
著者名 Kawabata, Jun
著者名 Odashima, Shizuo
e-Rad_Researcher 90125328 著者名 Takahashi, Koretaro
言語	英語
キーワード	fucoxanthin
	antiproliferation
	apoptosis
	DNA fragmentation
	HL-60 cell
発行日	1999
出版者	Japanese Society for Food Science and Technology
収録物名	Food Science and Technology Research
巻(号)	5(3)
ページ	243-246
記述	Note
抄録	The apoptosis-inducing effect of fucoxanthin on human leukemic HL-60 cells was investigated. Fucoxanthin, which was obtained from the brown alga Undaria pinnatifida, inhibited the proliferation of HL-60 cells and induced DNA fragmentation on agarose gel electrophoresis, a typical characteristic feature of apoptotic cells. The results of sandwich ELISA using anti-biotin-antibody and anti-DNA-antibody also demonstrated DNA fragmentation in accordance with the increase in fucoxanthin concentration and incubation time. Since the level of DNA fragmentation did not increase after 24 h incubation, fucoxanthin appeared to have some effect on cell cycle. In contrast, β-carotene did not show an apoptosis-inducing effect on HL-60 cells. These results suggested that a carotenoid structure might be crucial for inducing apoptosis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1344-6606
EISSN	1881-3984
NCID	AA11320122
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3136/fstr.5.243