Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil

Tsunoda, Masaru; Sakaue, Takeshi; Naito, Satoko et al.

Journal of Nucleic Acids, 2010, 2010, 1-10

Permalink : https://hdl.handle.net/2115/46984

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アクセス権
open access
URI
https://hdl.handle.net/2115/46984
タイトル
Insights into the Structures of DNA Damaged by Hydroxyl Radical: Crystal Structures of DNA Duplexes Containing 5-Formyluracil
著者
Tsunoda, Masaru ; Sakaue, Takeshi ; Naito, Satoko ; Sunami, Tomoko ; Abe, Naoko ; Ueno, Yoshihito ; Matsuda, Akira ; Takénaka, Akio
著者名
Tsunoda, Masaru
著者名
Sakaue, Takeshi
著者名
Naito, Satoko
著者名
Sunami, Tomoko
著者名
Abe, Naoko
著者名
Ueno, Yoshihito
著者名
Matsuda, Akira
著者名
Takénaka, Akio
言語
英語
発行日
2010
出版者
Hindawi Publishing
収録物名
Journal of Nucleic Acids
巻(号)
2010
ページ
1-10
抄録
Hydroxyl radicals are potent mutagens that attack DNA to form various base and ribose derivatives. One of the major damaged thymine derivatives is 5-formyluracil (fU), which induces pyrimidine transition during replication. In order to establish the structural basis for such mutagenesis, the crystal structures of two kinds of DNA d(CGCGRATfUCGCG) with R = A/G have been determined by X-ray crystallography. The fU residues form a Watson-Crick-type pair with A and two types of pairs (wobble and reversed wobble) with G, the latter being a new type of base pair between ionized thymine base and guanine base. In silico structural modeling suggests that the DNA polymerase can accept the reversed wobble pair with G, as well as the Watson-Crick pair with A.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-ShareAlike 2.1 Japan
EISSN
2090-021X
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.4061/2010/107289