Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis

Ishikawa, Noemia Kazue; Tahara, Satoshi; Namatame, Tomohiro; Farooq, Afgan; Fukushi, Yukiharu

Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis

Ishikawa, Noemia Kazue; Tahara, Satoshi; Namatame, Tomohiro et al.

Brazilian Journal of Microbiology, 2014, 44(4), 1285-1290

Permalink : https://hdl.handle.net/2115/56115

このアイテムのアクセス数:835件（2026-08-11 08:44 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
bmj-44-4-1285	pdf	762 KB	771

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/56115
タイトル	Use of P450 cytochrome inhibitors in studies of enokipodin biosynthesis
著者	Ishikawa, Noemia Kazue ; Tahara, Satoshi ; Namatame, Tomohiro ; Farooq, Afgan ; Fukushi, Yukiharu
著者名 Ishikawa, Noemia Kazue
著者名 Tahara, Satoshi
著者名 Namatame, Tomohiro
著者名 Farooq, Afgan
e-Rad_Researcher 60218906 著者名 Fukushi, Yukiharu
言語	英語
キーワード	Antimicrobial compound
	cuparene-1,4-quinone
	edible mushroom
	enokitake
	Flammulina velutipes
発行日	2014
出版者	Brazilian Society for Microbiology
収録物名	Brazilian Journal of Microbiology
巻(号)	44(4)
ページ	1285-1290
抄録	Enokipodins A, B, C, and D are antimicrobial sesquiterpenes isolated from the mycelial culture medium of Flammulina velutipes, an edible mushroom. The presence of a quaternary carbon stereo-center on the cyclopentane ring makes enokipodins A-D attractive synthetic targets. In this study, nine different cytochrome P450 inhibitors were used to trap the biosynthetic intermediates of highly oxygenated cuparene-type sesquiterpenes of F. velutipes. Of these, 1-aminobenzotriazole produced three less-highly oxygenated biosynthetic intermediates of enokipodins A-D; these were identified as (S)-(-)-cuparene-1,4-quinone and epimers at C-3 of 6-hydroxy-6-methyl-3-(1,2,2-trimethylcyclopentyl)- 2-cyclohexen-1-one. One of the epimers was found to be a new compound.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 3.0 Unported
PISSN	1517-8382