MicroRNA expression profiling of cat and dog kidneys

Ichii, Osamu; Otsuka, Saori; Ohta, Hiroshi; Yabuki, Akira; Horino, Taro; Kon, Yasuhiro

MicroRNA expression profiling of cat and dog kidneys

Ichii, Osamu; Otsuka, Saori; Ohta, Hiroshi et al.

Research in Veterinary Science, 2014, 96(2), 299-303

Permalink : https://hdl.handle.net/2115/56453

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/56453
タイトル	MicroRNA expression profiling of cat and dog kidneys
著者	Ichii, Osamu ; Otsuka, Saori ; Ohta, Hiroshi ; Yabuki, Akira ; Horino, Taro ; Kon, Yasuhiro
e-Rad_Researcher 60547769 著者名 Ichii, Osamu
e-Rad_Researcher 10566152 著者名 Otsuka, Saori
e-Rad_Researcher 50431333 著者名 Ohta, Hiroshi
e-Rad_Researcher 10315400 著者名 Yabuki, Akira
著者名 Horino, Taro
e-Rad_Researcher 10178402 著者名 Kon, Yasuhiro
言語	英語
キーワード	Companion animals
	Cat
	Dog
	MicroRNA
	Kidney
	RNA sequencing
発行日	2014-04
出版者	Elsevier
収録物名	Research in Veterinary Science
巻(号)	96(2)
ページ	299-303
抄録	MicroRNAs (miRNAs) play a role in the pathogenesis of certain diseases and may serve as biomarkers. Here, we present the first analysis of miRNA expression in the kidneys of healthy cats and dogs. Kidneys were divided into renal cortex (CO) and medulla (MD), and RNA sequence analysis was performed using the mouse genome as a reference. A total of 277, 276, 295, and 297 miRNAs were detected in cat CO, cat MD, dog CO, and dog MD, respectively. By comparing the expression ratio of CO to MD, we identified highly expressed miRNAs in each tissue as follows: 41 miRNAs including miR-192-5p in cat CO; 45 miRNAs including miR-323-3p in dog CO; 78 miRNAs including miR-20a-5p in cat MD; and 11 miRNAs including miR-132-5p in dog MD. Further, the target miRNAs of these miRNAs were identified. These data provide veterinary medicine critical information regarding renal miRNA expression. (C) 2014 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0034-5288
関連情報	PMID 24530019
関連情報	URI http://www.sciencedirect.com/science/journal/00345288
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.rvsc.2014.01.003