Recent progress toward synthesis of chlorosulfolipids: total synthesis and methodology

Umezawa, Taiki; Matsuda, Fuyuhiko

Tetrahedron Letters, 2014, 55(19), 3003-3012

Permalink : https://hdl.handle.net/2115/56540

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アクセス権	open access
URI	https://hdl.handle.net/2115/56540
タイトル	Recent progress toward synthesis of chlorosulfolipids: total synthesis and methodology
著者	著者名 Umezawa, Taiki
著者	e-Rad_Researcher 10219446 著者名 Matsuda, Fuyuhiko
言語	英語
キーワード	Chlorosulfolipid
	Total synthesis
	1,2-Dichlorination
	Epoxide opening by chloride
発行日	2014-05-07
出版者	Elsevier
収録物名	Tetrahedron Letters
巻(号)	55(19)
ページ	3003-3012
抄録	Chlorosulfolipids (CSLs) are an intriguing family of natural products featuring highly chlorinated linear hydrocarbon skeletons. Although CSLs were first isolated in 1962, chemical synthesis of CSLs was hampered because relevant methods for stereoselective construction of the polychlorinated motifs of CSLs were scarce. Since Carreira's first total synthesis of the CSL mytilipin A in 2009, several groups, including our own, have reported total syntheses of CSLs. As a result of these total syntheses, important progress has been made in the development of reliable synthetic methods for stereoselective polychlorination. In this digest, we summarize the total syntheses of CSLs by focusing on synthetic methods for stereoselective polychlorination of the organic frameworks of CSLs.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	© 2014 Published by Elsevier Ltd.
PISSN	0040-4039
NCID	AA00861801
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tetlet.2014.03.082