Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal

Paudel, Sarad; Mikota, Susan K.; Nakajima, Chie; Gairhe, Kamal P.; Maharjan, Bhagwan; Thapa, Jeewan; Poudel, Ajay; Shimozuru, Michito; Suzuki, Yasuhiko; Tsubota, Toshio

Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal

Paudel, Sarad; Mikota, Susan K.; Nakajima, Chie et al.

Tuberculosis, 2014, 94(3), 287-292

Permalink : https://hdl.handle.net/2115/56576

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/56576
タイトル	Molecular characterization of Mycobacterium tuberculosis isolates from elephants of Nepal
著者	Paudel, Sarad ; Mikota, Susan K. ; Nakajima, Chie ; Gairhe, Kamal P. ; Maharjan, Bhagwan ; Thapa, Jeewan ; Poudel, Ajay ; Shimozuru, Michito ; Suzuki, Yasuhiko ; Tsubota, Toshio
著者名 Paudel, Sarad
著者名 Mikota, Susan K.
e-Rad_Researcher 60435964 著者名 Nakajima, Chie
著者名 Gairhe, Kamal P.
著者名 Maharjan, Bhagwan
著者名 Thapa, Jeewan
著者名 Poudel, Ajay
著者名 Shimozuru, Michito
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
e-Rad_Researcher 10207441 著者名 Tsubota, Toshio
言語	英語
キーワード	Asian elephants
	Mycobacterium tuberculosis
	Multi-locus variable number tandem repeat analysis (MLVA)
	Spoligotyping
発行日	2014-05
出版者	Elsevier
収録物名	Tuberculosis
巻(号)	94(3)
ページ	287-292
抄録	Mycobacterium tuberculosis was cultured from the lung tissues of 3 captive elephants in Nepal that died with extensive lung lesions. Spoligotyping, TbD1 detection and multi-locus variable number of tandem repeat analysis (MLVA) results suggested 3 isolates belonged to a specific lineage of Indo-Oceanic clade, EAI5 SIT 138. One of the elephant isolates had a new synonymous single nucleotide polymorphism (SNP) T231C in the gyrA sequence, and the same SNP was also found in human isolates in Nepal. MLVA results and transfer history of the elephants suggested that 2 of them might be infected with M. tuberculosis from the same source. These findings indicated the source of M. tuberculosis infection of those elephants were local residents, presumably their handlers. Further investigation including detailed genotyping of elephant and human isolates is needed to clarify the infection route and eventually prevent the transmission of tuberculosis to susceptible hosts. (C) 2014 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1472-9792
NCID	AA11658683
関連情報	PMID 24566285
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tube.2013.12.008