Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers

Yamada, Tamaki; Tsuda, Masumi; Wagatsuma, Takanori; Fujioka, Yoichiro; Fujioka, Mari; Satoh, Aya O.; Horiuchi, Kosui; Nishide, Shinya; Nanbo, Asuka; Totsuka, Yasunori; Haga, Hisashi; Tanaka, Shinya; Shindoh, Masanobu; Ohba, Yusuke

Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers

Yamada, Tamaki; Tsuda, Masumi; Wagatsuma, Takanori et al.

Scientific reports, 2016, 6, 23545

Permalink : https://hdl.handle.net/2115/61496

このアイテムのアクセス数:1,132件（2026-08-17 23:45 集計）

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srep23545	pdf	4.61 MB	815
srep23545-s1	mov	1.31 MB	86	Supplementary Movie S1. The trafficking of active integrin β1 in C1 cells, related to Fig. 6
srep23545-s2	mov	3.31 MB	78	Supplementary Movie S2. The trafficking of active integrin β1 in R2 cells, related to Fig. 6.

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アクセス権	open access
URI	https://hdl.handle.net/2115/61496
タイトル	Receptor activator of NF-κB ligand induces cell adhesion and integrin α2 expression via NF-κB in head and neck cancers
著者	Yamada, Tamaki ; Tsuda, Masumi ; Wagatsuma, Takanori ; Fujioka, Yoichiro ; Fujioka, Mari ; Satoh, Aya O. ; Horiuchi, Kosui ; Nishide, Shinya ; Nanbo, Asuka ; Totsuka, Yasunori ; Haga, Hisashi ; Tanaka, Shinya ; Shindoh, Masanobu ; Ohba, Yusuke
e-Rad_Researcher 80580943 著者名 Yamada, Tamaki
e-Rad_Researcher 30431307 著者名 Tsuda, Masumi
著者名 Wagatsuma, Takanori
著者名 Fujioka, Yoichiro
著者名 Fujioka, Mari
著者名 Satoh, Aya O.
著者名 Horiuchi, Kosui
e-Rad_Researcher 40451398 著者名 Nishide, Shinya
e-Rad_Researcher 60359487 著者名 Nanbo, Asuka
e-Rad_Researcher 00109456 著者名 Totsuka, Yasunori
e-Rad_Researcher 00292045 著者名 Haga, Hisashi
e-Rad_Researcher 70261287 著者名 Tanaka, Shinya
e-Rad_Researcher 20162802 著者名 Shindoh, Masanobu
e-Rad_Researcher 30333503 著者名 Ohba, Yusuke
言語	英語
発行日	2016-03-24
出版者	Nature Publishing Group
収録物名	Scientific reports
巻(号)	6
ページ	23545
抄録	Cellular interactions with the extracellular matrix play critical roles in tumor progression. We previously reported that receptor activator of NF-κB ligand (RANKL) specifically facilitates head and neck squamous cell carcinoma (HNSCC) progression in vivo. Here, we report a novel role for RANKL in the regulation of cell adhesion. Among the major type I collagen receptors, integrin α2 was significantly upregulated in RANKL-expressing cells, and its knockdown suppressed cell adhesion. The mRNA abundance of integrin α2 positively correlated with that of RANKL in human HNSCC tissues. We also revealed that RANK-NF-κB signaling mediated integrin α2 expression in an autocrine/paracrine manner. Interestingly, the amount of active integrin β1 on the cell surface was increased in RANKL-expressing cells through the upregulation of integrin α2 and endocytosis. Moreover, the RANK-integrin α2 pathway contributed to RANKL-dependent enhanced survival in a collagen gel and inhibited apoptosis in a xenograft model, demonstrating an important role for RANKL-mediated cell adhesion in three-dimensional environments.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
PISSN	2045-2322
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1038/srep23545