Clinical prognostic value of DNA methylation in hepatoblastoma : Four novel tumor suppressor candidates

Honda, Shohei; Minato, Masashi; Suzuki, Hiromu et al.

Cancer science, 2016, 107(6), 812-819

Permalink : https://hdl.handle.net/2115/62711

このアイテムのアクセス数:1,175件（2026-10-08 05:12 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
Honda_et_al-2016-Cancer_Science pdf 330 KB 747
cas12928-sup-0001-FigS1 tif 530 KB 207 Supporting Information: Fig. S1.
cas12928-sup-0002-FigS1b tif 467 KB 179 Supporting Information: Fig. S1.
cas12928-sup-0003-FigS2 tif 275 KB 188 Supporting Information: Fig. S2.
cas12928-sup-0004-FigS3 tif 104 KB 214 Supporting Information: Fig. S3.
cas12928-sup-0005-FigS4 tif 174 KB 202 Supporting Information: Fig. S4.
cas12928-sup-0006-FigS5 tif 160 KB 198 Supporting Information: Fig. S5.
as12928-sup-0007-TableS1 docx 18.3 KB 318 Supporting Information: Table S1.
as12928-sup-0008-TableS2 docx 19.9 KB 320 Supporting Information: Table S2.
as12928-sup-0009-TableS3 docx 15.8 KB 339 Supporting Information: Table S3.
as12928-sup-0010-TableS4 docx 15.3 KB 311 Supporting Information: Table S4.
as12928-sup-0011-TableS5 docx 16.2 KB 321 Supporting Information: Table S5.
as12928-sup-0012-TableS6 docx 17.4 KB 334 Supporting Information: Table S6.

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/62711
タイトル
Clinical prognostic value of DNA methylation in hepatoblastoma : Four novel tumor suppressor candidates
著者
Honda, Shohei ; Minato, Masashi ; Suzuki, Hiromu ; Fujiyoshi, Masato ; Miyagi, Hisayuki ; Haruta, Masayuki ; Kaneko, Yasuhiko ; Hatanaka, Kanako C. ; Hiyama, Eiso ; Kamijo, Takehiko ; Okada, Tadao ; Taketomi, Akinobu
e-Rad_Researcher
90588089
著者名
Honda, Shohei
著者名
Minato, Masashi
e-Rad_Researcher
20381254
著者名
Suzuki, Hiromu
著者名
Fujiyoshi, Masato
著者名
Miyagi, Hisayuki
e-Rad_Researcher
80392190
著者名
Haruta, Masayuki
e-Rad_Researcher
50373387
著者名
Kaneko, Yasuhiko
著者名
Hatanaka, Kanako C.
e-Rad_Researcher
00218744
著者名
Hiyama, Eiso
著者名
Kamijo, Takehiko
著者名
Okada, Tadao
e-Rad_Researcher
70363364
著者名
Taketomi, Akinobu
言語
英語
キーワード
Hepatoblastoma
methylation
prognostic marker
survival
tumor suppressor
発行日
2016-06
出版者
Japanese Cancer Association
収録物名
Cancer science
巻(号)
107(6)
ページ
812-819
抄録
Hepatoblastoma (HB) is very rare but the most common malignant neoplasm of the liver occurring in children. Despite improvements in therapy, outcomes for patients with advanced HB that is refractory to standard preoperative chemotherapy remain unsatisfactory. To improve the survival rate among this group, identification of novel prognostic markers and therapeutic targets is needed. We have previously reported that altered DNA methylation patterns are of biological and clinical importance in HB. In the present study, using genome-wide methylation analysis and bisulfite pyrosequencing with specimens from HB tumors, we detected nine methylated genes. We then focused on four of those genes, GPR180, MST1R, OCIAD2, and PARP6, because they likely encode tumor suppressors and their increase of methylation was associated with a poor prognosis. The methylation status of the four genes was also associated with age at diagnosis, and significant association with the presence of metastatic tumors was seen in three of the four genes. Multivariate analysis revealed that the presence of metastatic tumors and increase of methylation of GPR180 were independent prognostic factors affecting event-free survival. These findings indicate that the four novel tumor suppressor candidates are potentially useful molecular markers predictive of a poor outcome in HB patients, which may serve as the basis for improved therapeutic strategies when clinical trials are carried out.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
PISSN
1347-9032
NCID
AA11808050
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1111/cas.12928