Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice

Aoki, Shiho; Iwai, Atsushi; Kawata, Koji; Muramatsu, Daisuke; Uchiyama, Hirofumi; Okabe, Mitsuyasu; Ikesue, Masahiro; Maeda, Naoyoshi; Uede, Toshimitsu

Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice

Aoki, Shiho; Iwai, Atsushi; Kawata, Koji et al.

Journal of Functional Foods, 2015, 18, 22-27

Permalink : https://hdl.handle.net/2115/63473

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アクセス権	open access
URI	https://hdl.handle.net/2115/63473
タイトル	Oral administration of the β-glucan produced by Aureobasidium pullulans ameliorates development of atherosclerosis in apolipoprotein E deficient mice
著者	Aoki, Shiho ; Iwai, Atsushi ; Kawata, Koji ; Muramatsu, Daisuke ; Uchiyama, Hirofumi ; Okabe, Mitsuyasu ; Ikesue, Masahiro ; Maeda, Naoyoshi ; Uede, Toshimitsu
著者名 Aoki, Shiho
著者名 Iwai, Atsushi
著者名 Kawata, Koji
著者名 Muramatsu, Daisuke
著者名 Uchiyama, Hirofumi
著者名 Okabe, Mitsuyasu
著者名 Ikesue, Masahiro
著者名 Maeda, Naoyoshi
e-Rad_Researcher 00160185 著者名 Uede, Toshimitsu
言語	英語
キーワード	β-glucan
	Aureobasidium pullulans
	Atherosclerosis
発行日	2015-10
出版者	Elsevier
収録物名	Journal of Functional Foods
巻(号)	18
ページ	22-27
抄録	The Aureobasidium pullulans-produced β-glucan (AP-PG) is an immune stimulator, and believed to exhibit beneficial effects on health through its immune stimulating activity. Here, the effect of oral administration of AP-PG on high-fat diet (HFD)-induced atherosclerosis was evaluated using apolipoprotein E deficient mice, a widely used mouse model for atherosclerosis. The results demonstrated that HFD-induced development of atherosclerosis was significantly reduced in the AP-PG-treated mice when compared with that of the control mice. In serological analysis, blood levels of oxidized low-density lipoprotein cholesterol, a well-known risk factor for the development of atherosclerosis, were significantly reduced in the AP-PG-treated group of mice. Further, immunohistochemical analysis using MOMA-2 antibody showed that oral administration of AP-PG is effective in ameliorating vascular accumulation of macrophages. These data suggest the possibility that oral administration of AP-PG is effective in ameliorating HFD-induced development of atherosclerosis.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1756-4646
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.jff.2015.06.044