A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

Maeda, Kenichiro; Yasui, Hironobu; Yamamori, Tohru; Matsuura, Taeko; Takao, Seishin; Suzuki, Motofumi; Matsuda, Akira; Inanami, Osamu; Shirato, Hiroki

A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

Maeda, Kenichiro; Yasui, Hironobu; Yamamori, Tohru et al.

PLOS One, 2016, 11(11), e0166848

Permalink : https://hdl.handle.net/2115/63679

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アクセス権	open access
URI	https://hdl.handle.net/2115/63679
タイトル	A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam
著者	Maeda, Kenichiro ; Yasui, Hironobu ; Yamamori, Tohru ; Matsuura, Taeko ; Takao, Seishin ; Suzuki, Motofumi ; Matsuda, Akira ; Inanami, Osamu ; Shirato, Hiroki
著者名 Maeda, Kenichiro
e-Rad_Researcher 10570228 著者名 Yasui, Hironobu
e-Rad_Researcher 00512675 著者名 Yamamori, Tohru
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
e-Rad_Researcher 10614216 著者名 Takao, Seishin
著者名 Suzuki, Motofumi
e-Rad_Researcher 90157313 著者名 Matsuda, Akira
e-Rad_Researcher 10193559 著者名 Inanami, Osamu
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
発行日	2016-11-22
出版者	The Public Library of Science
収録物名	PLOS One
巻(号)	11(11)
ページ	e0166848
抄録	The effect of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton beams. Treatment with ECyd significantly enhanced the proton-induced loss of clonogenicity and increased senescence at the center, but not at the distal edge of SOBP. The p53-binding protein 1 foci formation assay showed that ECyd decelerated the rate of DNA double-strand break (DSB) repair at the center, but not the distal region of SOBP, suggesting that the ECyd-induced enhancement of proton-induced cell death is partially associated with the inhibition of DSB repair. This study demonstrated that ECyd enhances proton-induced cell killing at all positions of SOBP, except for the distal region and minimizes the site-dependent differences in RBE within SOBP. Thus, ECyd is a unique radiosensitizer for proton therapy that may be useful because it levels the biological dose within SOBP, which improves tumor control and reduces the risk of adverse effects at the distal edge of SOBP.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
EISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0166848