Flow Behavior and Distribution of Embolus-Model Particles at the Terminal Bifurcation of the Human Internal Carotid Artery

Kobayashi, Nobuaki; Karino, Takeshi

Flow Behavior and Distribution of Embolus-Model Particles at the Terminal Bifurcation of the Human Internal Carotid Artery

Kobayashi, Nobuaki; Karino, Takeshi

World neurosurgery, 2016, 90, 469-477

Permalink : https://hdl.handle.net/2115/65783

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Kobayashi & Karino final	pdf	237 KB	492
Highlights	pdf	44.9 KB	287	Highlights
Cover letter	pdf	39.6 KB	568	Cover letter
Kobayashi 2 Fig. 1 final	jpg	42.2 KB	106	Fig. 1
Kobayashi 2 Fig. 2 final 1	jpg	501 KB	159	Fig. 2
Kobayashi 2 Fig. 3 final	jpg	0.98 MB	120	Fig. 3
Kobayashi 2 Fig. 4 final	jpg	1.43 MB	111	Fig. 4
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KobayashiTable1-3	pdf	47.7 KB	358	Table

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/65783
タイトル	Flow Behavior and Distribution of Embolus-Model Particles at the Terminal Bifurcation of the Human Internal Carotid Artery
著者	著者名 Kobayashi, Nobuaki
著者	e-Rad_Researcher 30241384 著者名 Karino, Takeshi
言語	英語
キーワード	Anterior cerebral artery
	Cerebral embolism
	Embolization
	Flow pattern
	Hemodynamics
	Internal carotid artery
	Middle cerebral artery
	Particle flow behavior
発行日	2016-06
出版者	Elsevier
収録物名	World neurosurgery
巻(号)	90
ページ	469-477
抄録	BACKGROUND: To investigate the possible role of fluid mechanical factors in thromboembolism that occurs at a high rate in the human middle cerebral artery (MCA). METHODS: Isolated transparent cerebral arterial trees containing the terminal bifurcation of the internal carotid artery (ICA), where the ICA bifurcated into the MCA and the anterior cerebral artery, were prepared from human cadavers. The flow behavior and distribution of embolus-model polystyrene particles in dilute suspensions at the bifurcation were studied in detail by means of flow visualization and high-speed cinemicrographic techniques. RESULTS: Large particles in suspensions flowing through the ICA migrated radially away from the vessel wall toward the axis of the ICA. It became more remarkable by increasing the flow rate in the ICA (Q(0)), flow rate ratio of Q(1) to Q(0) (MCA/ICA), and particle diameter. As a result, redistribution of particles flowing in the ICA occurred at the bifurcation. The particles >1 mm in diameter (approximate to 1/4 of vessel diameter) selectively entered the MCA, even when the flow rate ratio of Q(1) to Q(0) was decreased to as low as 0.34. In contrast, the particles whose diameters were <0.3 mm (approximate to 1/10 of vessel diameter) and that did not show radial migration entered the MCA at the same rate as the flow rate ratio of Q(1) to Q(0). CONCLUSIONS: Due to the flow-dependent migration of particles away from the vessel wall toward the axis of the ICA, large particles selectively enter the MCA to which the core flow of the ICA is generally directed. This might explain why the incidence of thromboembolism is higher in the MCA than in the anterior cerebral artery in humans.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	1878-8750
関連情報	PMID 26987631
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.wneu.2016.03.012