Computed tomography (CT)-assessed bronchodilation induced by inhaled indacaterol and glycopyrronium/indacaterol in COPD

Shimizu, Kaoruko; Seto, Ruriko; Makita, Hironi; Suzuki, Masaru; Konno, Satoshi; Ito, Yoichi M.; Kanda, Rie; Ogawa, Emiko; Nakano, Yasutaka; Nishimura, Masaharu

Computed tomography (CT)-assessed bronchodilation induced by inhaled indacaterol and glycopyrronium/indacaterol in COPD

Shimizu, Kaoruko; Seto, Ruriko; Makita, Hironi et al.

Respiratory medicine, 2016, 119, 70-77

Permalink : https://hdl.handle.net/2115/67226

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アクセス権	open access
URI	https://hdl.handle.net/2115/67226
タイトル	Computed tomography (CT)-assessed bronchodilation induced by inhaled indacaterol and glycopyrronium/indacaterol in COPD
著者	Shimizu, Kaoruko ; Seto, Ruriko ; Makita, Hironi ; Suzuki, Masaru ; Konno, Satoshi ; Ito, Yoichi M. ; Kanda, Rie ; Ogawa, Emiko ; Nakano, Yasutaka ; Nishimura, Masaharu
e-Rad_Researcher 40399853 著者名 Shimizu, Kaoruko
著者名 Seto, Ruriko
e-Rad_Researcher 70533537 著者名 Makita, Hironi
e-Rad_Researcher 10374290 著者名 Suzuki, Masaru
e-Rad_Researcher 20399835 著者名 Konno, Satoshi
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
著者名 Kanda, Rie
e-Rad_Researcher 00378671 著者名 Ogawa, Emiko
e-Rad_Researcher 00362377 著者名 Nakano, Yasutaka
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
キーワード	Bronchodilation
	β2 agonists
	Anticholinergics
	Pulmonary function tests
	Three-dimensional computed tomography
発行日	2016-10
出版者	Elsevier
収録物名	Respiratory medicine
巻(号)	119
ページ	70-77
抄録	Background: Our previous studies suggested that the site of bronchodilation on CT might differ between inhaled β2 agonists and inhaled anticholinergics in COPD. Aim: To assess and compare the bronchodilation effects of inhaled indacaterol and glycopyrronium/indacaterol by airway generation in large airways using CT. Methods: CT scans at full inspiration and pulmonary function tests were done in 25 patients with moderate-severe COPD before and 4-5 weeks after daily inhalation of indacaterol and again another 4-5 weeks after inhalation of glycopyrronium/indacaterol. Airway inner luminal area (Ai) at the 3rd (segmental) to 6th generation of 8 selected bronchi, a total of 32 sites, in the right lung was analyzed on 3 occasions. Our proprietary software enables us to select the same airways and the same measurement sites for comparison, with simultaneous confirmation using two screens on the computer. Results: The overall increase of Ai (ΔAi, %) averaged at all 32 measurement sites induced by glycopyrronium/indacaterol had a significant correlation with FEV1 improvement (r=0.7466, p<0.0001). Both ΔAi, % with indacaterol and ΔAi, % with additional glycopyrronium were significant at the 3rd to 6th generations. Remarkable increases in ΔAi, % were found at the 5th and 6th generations in several subjects with indacaterol or additional glycopyrronium. There were no significant site-differences in the bronchodilation pattern caused by indacaterol and by glycopyrronium/indacaterol at any of the 3rd to 6th generations. Conclusions: Additional bronchodilation with glycopyrronium was demonstrated by CT at the 3rd to 6th generations, with no site-specific differences in bronchodilation between indacaterol and glycopyrronium/indacaterol. This study was registered in the UMIN Clinical Trials Registry (UMIN-CTR) system (http://www.umin.ac.jp/. ID. UMIN000012043).
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0954-6111
関連情報	PMID 27692151
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.rmed.2016.08.020