Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702) : Results for the group with PTV ⩾ 100 cc

Onimaru, Rikiya; Onishi, Hiroshi; Shibata, Taro; Hiraoka, Masahiro; Ishikura, Satoshi; Karasawa, Katsuyuki; Matsuo, Yukinori; Kokubo, Masaki; Shioyama, Yoshiyuki; Matsushita, Haruo; Ito, Yoshinori; Shirato, Hiroki

Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702) : Results for the group with PTV ⩾ 100 cc

Onimaru, Rikiya; Onishi, Hiroshi; Shibata, Taro et al.

Radiotherapy and Oncology, 2017, 122(2), 281-285

Permalink : https://hdl.handle.net/2115/68254

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Appendix2	pptx	79.9 KB	235	Supplementary data 2

論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/68254
タイトル	Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lung cancer (JCOG0702) : Results for the group with PTV ⩾ 100 cc
その他のタイトル	Dose escalation study of SBRT : JCOG 0702
著者	Onimaru, Rikiya ; Onishi, Hiroshi ; Shibata, Taro ; Hiraoka, Masahiro ; Ishikura, Satoshi ; Karasawa, Katsuyuki ; Matsuo, Yukinori ; Kokubo, Masaki ; Shioyama, Yoshiyuki ; Matsushita, Haruo ; Ito, Yoshinori ; Shirato, Hiroki
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 30213804 著者名 Onishi, Hiroshi
著者名 Shibata, Taro
e-Rad_Researcher 70173218 著者名 Hiraoka, Masahiro
著者名 Ishikura, Satoshi
著者名 Karasawa, Katsuyuki
e-Rad_Researcher 80456897 著者名 Matsuo, Yukinori
e-Rad_Researcher 90283605 著者名 Kokubo, Masaki
e-Rad_Researcher 10323304 著者名 Shioyama, Yoshiyuki
e-Rad_Researcher 20302250 著者名 Matsushita, Haruo
著者名 Ito, Yoshinori
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	dose escalation study
	continual reassessment method
	non-small cell lung cancer (NSCLC)
	stereotactic body radiotherapy
	SBRT
発行日	2017-02
出版者	Elsevier
収録物名	Radiotherapy and Oncology
巻(号)	122(2)
ページ	281-285
抄録	Purpose: A dose escalation study to determine the recommended dose (RD) with stereotactic body radiation therapy (SBRT) for peripheral T2N0M0 non-small cell carcinomas (NSCLC) was conducted. The results of the group with PTV ⩾ 100 cc is reported in this paper. Materials and Methods: The continual reassessment method (CRM) was used to determine the dose level that patients should be assigned to and to estimate the maximum tolerated dose (MTD). Dose limiting toxicity (DLT) was Grade 3 or higher radiation pneumonitis (RP), and Grade 2 or higher RP was used as a surrogate DLT. The RD was equal to the MTD. The dose was prescribed at D95 of the PTV. Results: Thirteen patients were accrued. More patients should have been enrolled but we decided not to prolong the study period. No patients experienced Grade 3 RP. Two patients experienced Grade 2 RP at 50 Gy in 4 fractions. The predicted MTD was 50.2 Gy. The posterior probability of the Grade 2 RP frequency over 40% was 5.3% for the dose level of 50 Gy. The RD was determined to be 50 Gy. Conclusions: The RD was determined to be 50 Gy in 4 fractions in this population.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
PISSN	0167-8140
関連情報	PMID 27993416
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.radonc.2016.11.022