Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin

Tateyama, Akito; Kato, Akihito; Miyaji, Hirofumi et al.

Nano Biomedicine, 2017, 9(2), 69-76

Permalink : https://hdl.handle.net/2115/68466

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/68466
タイトル
Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin
著者
Tateyama, Akito ; Kato, Akihito ; Miyaji, Hirofumi ; Nishida, Erika ; Iwasaki, Yasuhiro ; Fujii, Syuji ; Kawamoto, Kohei ; Shitomi, Kanako ; Furihata, Tomokazu ; Mayumi, Kayoko ; Sugaya, Tsutomu
著者名
Tateyama, Akito
e-Rad_Researcher
40507571
著者名
Kato, Akihito
e-Rad_Researcher
50372256
著者名
Miyaji, Hirofumi
著者名
Nishida, Erika
著者名
Iwasaki, Yasuhiro
著者名
Fujii, Syuji
著者名
Kawamoto, Kohei
著者名
Shitomi, Kanako
著者名
Furihata, Tomokazu
著者名
Mayumi, Kayoko
e-Rad_Researcher
10211301
著者名
Sugaya, Tsutomu
言語
英語
キーワード
α-tricalcium phosphate (TCP)
bone tissue engineering
bone paste
water-oil emulsion
simvastatin
発行日
2017-12-30
出版者
ナノ・バイオメディカル学会
Nano Biomedical Society
収録物名
Nano Biomedicine
巻(号)
9(2)
ページ
69-76
抄録
To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects. Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1883-5198
EISSN
2185-4734
NCID
AA12510316
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.11344/nano.9.69