Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system

Nishioka, Kentaro; Prayongrat, Anussara; Ono, Kota; Onodera, Shunsuke; Hashimoto, Takayuki; Katoh, Norio; Inoue, Tetsuya; Kinoshita, Rumiko; Yasuda, Koichi; Mori, Takashi; Onimaru, Rikiya; Shirato, Hiroki; Shimizu, Shinichi

Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system

Nishioka, Kentaro; Prayongrat, Anussara; Ono, Kota et al.

Journal of Radiation Research, 2018, 59(suppl_1), i63-i71

Permalink : https://hdl.handle.net/2115/70251

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アクセス権	open access
URI	https://hdl.handle.net/2115/70251
タイトル	Prospective study to evaluate the safety of the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy system
著者	Nishioka, Kentaro ; Prayongrat, Anussara ; Ono, Kota ; Onodera, Shunsuke ; Hashimoto, Takayuki ; Katoh, Norio ; Inoue, Tetsuya ; Kinoshita, Rumiko ; Yasuda, Koichi ; Mori, Takashi ; Onimaru, Rikiya ; Shirato, Hiroki ; Shimizu, Shinichi
e-Rad_Researcher 80463743 著者名 Nishioka, Kentaro
著者名 Prayongrat, Anussara
著者名 Ono, Kota
著者名 Onodera, Shunsuke
e-Rad_Researcher 60400678 著者名 Hashimoto, Takayuki
e-Rad_Researcher 80572495 著者名 Katoh, Norio
e-Rad_Researcher 10431363 著者名 Inoue, Tetsuya
e-Rad_Researcher 70507582 著者名 Kinoshita, Rumiko
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
著者名 Mori, Takashi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
言語	英語
キーワード	spot-scanning
	synchrotron-based
	proton beam therapy
	safety
	toxicity
	adverse event
発行日	2018-03
出版者	Oxford University Press
収録物名	Journal of Radiation Research
巻(号)	59(suppl_1)
ページ	i63-i71
抄録	This is a report of a single-institution prospective study evaluating the safety of a spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam therapy (PBT) system. Data collection was performed for 56 patients with 59 treatment sites who received proton beam therapy at Hokkaido University Hospital between March 2014 and July 2015. Forty-one patients were male and 15 were female. The median age was 66 years. The primary lesion sites were prostate (n = 17), bone/soft tissue (n = 10), liver (n = 7), lung (n = 6), central nervous system (n = 5), colon (n = 2), pancreas (n = 2), kidney (n = 2) and others (n = 5). Chemotherapy was administered in 11 patients. The prescribed total dose was from 20 to 76 GyE (Radiobiological equivalent dose, RBE = 1.1), with the median dose of 65 GyE in 4 to 35 fractions. No PBT-related Common Terminology Criteria for Adverse Events Grade 4 or 5 toxicities were observed; the incidence of early PBT-related Grade 4 adverse events was 0% (95% confidence interval 0 to 6.38%). The most common Grade 3 toxicities were hematologic toxicity (12.5%) unlikely to be related to the PBT. One patient developed a left femoral neck fracture (Grade 3) at 14.5 months after PBT for chondrosarcoma of the left pelvis. The pathological findings showed no other malignancies, suggesting that it was possibly related to the PBT. In conclusion, the spot-scanning dedicated, synchrotron-based PBT system is feasible, but further studies on its long-term safety and efficacy are warranted.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution-NonCommercial 4.0 International
PISSN	0449-3060
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1093/jrr/rrx083