pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives

Nakagawa, Shiori; Tachrim, Zetryana Puteri; Kurokawa, Natsumi; Ohashi, Fumina; Sakihama, Yasuko; Suzuki, Takeyuki; Hashidoko, Yasuyuki; Hashimoto, Makoto

pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives

Nakagawa, Shiori; Tachrim, Zetryana Puteri; Kurokawa, Natsumi et al.

Molecules, 2018, 23(8), 1943

Permalink : https://hdl.handle.net/2115/71933

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/71933
タイトル	pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives
著者	Nakagawa, Shiori ; Tachrim, Zetryana Puteri ; Kurokawa, Natsumi ; Ohashi, Fumina ; Sakihama, Yasuko ; Suzuki, Takeyuki ; Hashidoko, Yasuyuki ; Hashimoto, Makoto
著者名 Nakagawa, Shiori
著者名 Tachrim, Zetryana Puteri
著者名 Kurokawa, Natsumi
著者名 Ohashi, Fumina
e-Rad_Researcher 10344491 著者名 Sakihama, Yasuko
著者名 Suzuki, Takeyuki
e-Rad_Researcher 40281795 著者名 Hashidoko, Yasuyuki
e-Rad_Researcher 90292094 著者名 Hashimoto, Makoto
言語	英語
キーワード	cycloDOPA
	pH stability
	antioxidant power
発行日	2018-08-03
出版者	MDPI
収録物名	Molecules
巻(号)	23(8)
ページ	1943
抄録	CycloDOPA (leukodopachrome), a well known metabolite of tyrosine, is a precursor of melanine in mammalian organisms and of the pigment betalain in plants. However, the isolation of cycloDOPA from natural sources has not been widely reported. In the present work, the stabilities of cycloDOPA and cycloDOPA methyl ester at various pH levels were studied. Both compounds were stable under acidic conditions. By contrast, both compounds were unstable when the pH was shifted from neutral to basic to form indole derivatives as major products. Based on the pH stability, cycloDOPA and its derivatives were subjected to the DPPH radical scavenging assay for the first time.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 4.0 International
権利情報	© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
PISSN	1420-3049
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.3390/molecules23081943