Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner

Nakatani, Yuka; Kiyonari, Hiroshi; Kondo, Toru

Development, 2019, 146(4), dev168120

Permalink : https://hdl.handle.net/2115/76648

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アクセス権
open access
URI
https://hdl.handle.net/2115/76648
タイトル
Ecrg4 deficiency extends the replicative capacity of neural stem cells in a Foxg1-dependent manner
著者
Nakatani, Yuka ; Kiyonari, Hiroshi ; Kondo, Toru
著者名
Nakatani, Yuka
著者名
Kiyonari, Hiroshi
e-Rad_Researcher
30270573
著者名
Kondo, Toru
言語
英語
キーワード
Ecrg4
Neural stem cells (NSCs)
Foxg1
Aging
Memory
発行日
2019-02
出版者
Company of Biologists
収録物名
Development
巻(号)
146(4)
ページ
dev168120
抄録
The self-renewal activity of neural stem cells (NSCs) has been suggested to decrease with aging, resulting in age-dependent declines in brain function, such as presbyopia and memory loss. The molecular mechanisms underlying decreases in NSC proliferation with age need to be elucidated in more detail to develop treatments that promote brain function. We have previously reported that the expression of esophageal cancer-related gene 4 (Ecrg4) was upregulated in aged NSCs, whereas its overexpression decreased NSC proliferation, suggesting a functional relationship between Ecrg4 and NSC aging. Using Ecrg4-deficient mice in which the Ecrg4 locus was replaced with the lacZ gene, we here show that Ecrg4 deficiency recovered the age-dependent decline in NSC proliferation and enhanced spatial learning and memory in the Morris water-maze paradigm. We demonstrate that the proliferation of Ecrg4-deficient NSCs was partly maintained by the increased expression of Foxg1. Collectively, these results determine Ecrg4 as a NSC aging factor.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0950-1991
EISSN
1477-9129
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1242/dev.168120