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アクセス権	open access
URI	https://hdl.handle.net/2115/76980
タイトル	Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.
著者	Gao, Lei ; Narita, Koji ; Ozaki, Taro ; Kumakura, Naoyoshi ; Gan, Pamela ; Minami, Atsushi ; Liu, Chengwei ; Lei, Xiaoguang ; Shirasu, Ken ; Oikawa, Hideaki
著者名 Gao, Lei
著者名 Narita, Koji
著者名 Ozaki, Taro
著者名 Kumakura, Naoyoshi
著者名 Gan, Pamela
e-Rad_Researcher 40507191 著者名 Minami, Atsushi
著者名 Liu, Chengwei
著者名 Lei, Xiaoguang
著者名 Shirasu, Ken
e-Rad_Researcher 00185175 著者名 Oikawa, Hideaki
言語	英語
キーワード	Sesterterpene synthase
	Genome mining
	Natural product biosynthesis
	Phytopathogen
	Heterologous expression
発行日	2018-03-21
出版者	Elsevier
収録物名	Tetrahedron Letters
巻(号)	59(12)
ページ	1136-1139
抄録	Two homologous gene clusters for the biosynthesis of sesterterpenes betaestacins were identified from two phytopathogens, Phoma betae and Colletotrichum orbiculare. Heterologous expression of identified oxidation enzymes with previously-characterized PbTS1 (BtcA(pb)) resulted in the production of seven novel sesterterpenes. Although both strains possessed homologous enzymes, oxidation state of corresponding products were different from each other, suggesting that structural diversification of sesterterpene skeletons might be achieved by these homologous enzymes with different functions. (C) 2013 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
権利情報	©2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
PISSN	0040-4039
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tetlet.2018.02.022

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