Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate

Hashizume, Mei; Aoki, Koki; Ohno, Shigeaki; Kitaichi, Nobuyoshi; Yawata, Nobuyo; Gonzalez, Gabriel; Nonaka, Hirotaka; Sato, Seiichi; Takaoka, Akinori

Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate

Hashizume, Mei; Aoki, Koki; Ohno, Shigeaki et al.

European journal of ophthalmology, 2021, 31(2), 379-384

Permalink : https://hdl.handle.net/2115/81697

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アクセス権	open access
URI	https://hdl.handle.net/2115/81697
タイトル	Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate
著者	Hashizume, Mei ; Aoki, Koki ; Ohno, Shigeaki ; Kitaichi, Nobuyoshi ; Yawata, Nobuyo ; Gonzalez, Gabriel ; Nonaka, Hirotaka ; Sato, Seiichi ; Takaoka, Akinori
著者名 Hashizume, Mei
著者名 Aoki, Koki
e-Rad_Researcher 50002382 著者名 Ohno, Shigeaki
e-Rad_Researcher 40431366 著者名 Kitaichi, Nobuyoshi
著者名 Yawata, Nobuyo
著者名 Gonzalez, Gabriel
著者名 Nonaka, Hirotaka
e-Rad_Researcher 60459724 著者名 Sato, Seiichi
e-Rad_Researcher 30323611 著者名 Takaoka, Akinori
言語	英語
キーワード	Human adenovirus
	epidemic keratoconjunctivitis
	disinfectants
	prevention
	RUBYSTA
	Virkon
発行日	2021-03
出版者	SAGE Publications
収録物名	European journal of ophthalmology
巻(号)	31(2)
ページ	379-384
抄録	Purpose: The aim of this study was to test the antiviral effectivity of potassium peroxymonosulfate (RUBYSTA (R), KYORIN) against five epidemic keratoconjunctivitis-related types of Human adenovirus D in vitro. Methods: Five types of Human adenovirus D (8, 37, 53, 54 and 56) were incubated with 1% potassium peroxymonosulfate, 0.1% sodium hypochlorite (NaClO) or alcohol-based disinfectant for 30 s or 1 min. These solutions were subjected to measurements of viral titres by infection assays in A549 cells. At day 6 post-infection, both, supernatants and cells, were collected and the viral genome was assessed by real-time polymerase chain reaction analysis. Results: Treatments with 1% potassium peroxymonosulfate led to significant reduction in all tested Human adenovirus D types comparable to disinfecting effects by 0.1% NaClO. Overall, potassium peroxymonosulfate demonstrated sufficient inactivation of the major epidemic keratoconjunctivitis-causing Human adenovirus D to be considered for disinfection and prevention purposes in ophthalmological clinics and hospitals. Conclusion: This study demonstrated that potassium peroxymonosulfate is a promising disinfectant for the prevention of epidemic keratoconjunctivitis nosocomial infections in ophthalmological clinics.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	Mei Hashizume, Koki Aoki, Shigeaki Ohno, Nobuyoshi Kitaichi, Nobuyo Yawata, Gabriel Gonzalez, Hirotaka Nonaka, Seiichi Sato, Akinori Takaoka, Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate Show less, European Journal of Ophthalmology Vol. 31(2) pp. 379-384. Copyright ©2021 (Copyright Holder). DOI:10.1177/1120672119891408
PISSN	1120-6721
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1177/1120672119891408